What stands out
This is a meaningful pathway in the sample.
Working interpretation
The working read here is lower androgen metabolism support.
Key markers
Free testosterone, SHBG, DHEA-S
Priority context
High. This is one of the clearest and most testable findings in the report.
Why it rose
Why this pathway surfaced
This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.
Free testosterone
Free testosterone gives practical context for whether androgen metabolism is showing up in real physiology.
SHBG
gives context on hormone availability and binding
DHEA-S
DHEA-S gives practical context for whether androgen metabolism is showing up in real physiology.
Main genes
Which genes are carrying the signal
SRD5A2
SRD5A2 adds weight to the same pathway interpretation, but does not drive it alone.
SRD5A2 adds androgen metabolism context and should be interpreted with the surrounding pathway pattern, not on its own.
HSD3B1
HSD3B1 adds weight to the same pathway interpretation, but does not drive it alone.
HSD3B1 adds androgen metabolism context and should be interpreted with the surrounding pathway pattern, not on its own.
SHBG
SHBG adds weight to the same pathway interpretation, but does not drive it alone.
SHBG adds androgen metabolism context and should be interpreted with the surrounding pathway pattern, not on its own.
CYP19A1
CYP19A1 adds weight to the same pathway interpretation, but does not drive it alone.
CYP19A1 adds androgen metabolism context and should be interpreted with the surrounding pathway pattern, not on its own.
COMT
COMT adds weight to the same pathway interpretation, but does not drive it alone.
COMT adds androgen metabolism context and should be interpreted with the surrounding pathway pattern, not on its own.