What stands out
This still stands out, but the signal is lighter than the top two pathways.
Working interpretation
The working read here is lower appetite / satiety support.
Key markers
Leptin, ghrelin, meal timing response
Priority context
High. This is one of the clearest and most testable findings in the report.
Why it rose
Why this pathway surfaced
This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.
Leptin
gives context on satiety signaling and how strongly fullness signals are landing
ghrelin
gives context on hunger signaling and meal-initiation pressure
meal timing response
shows whether hunger and fullness patterns look orderly or dysregulated
Main genes
Which genes are carrying the signal
MC4R
MC4R adds weight to the same pathway interpretation, but does not drive it alone.
MC4R adds appetite / satiety context and should be interpreted with the surrounding pathway pattern, not on its own.
NPY
NPY adds weight to the same pathway interpretation, but does not drive it alone.
NPY adds appetite / satiety context and should be interpreted with the surrounding pathway pattern, not on its own.
NPY2R
NPY2R adds weight to the same pathway interpretation, but does not drive it alone.
NPY2R adds appetite / satiety context and should be interpreted with the surrounding pathway pattern, not on its own.
GHRL
GHRL adds weight to the same pathway interpretation, but does not drive it alone.
GHRL adds appetite / satiety context and should be interpreted with the surrounding pathway pattern, not on its own.