What stands out
This pathway matters mainly as supporting context.
Working interpretation
The working read here is lower hepatic lipid export support.
Key markers
ALT / AST, triglycerides, liver-fat context
Priority context
Moderate. It is worth checking if symptoms or existing labs point in the same direction.
Why it rose
Why this pathway surfaced
This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.
ALT / AST
ALT / AST gives practical context for whether hepatic lipid export is showing up in real physiology.
triglycerides
Triglycerides gives practical context for whether hepatic lipid export is showing up in real physiology.
liver-fat context
Liver-fat context gives practical context for whether hepatic lipid export is showing up in real physiology.
Main genes
Which genes are carrying the signal
PNPLA3
PNPLA3 adds weight to the same pathway interpretation, but does not drive it alone.
PNPLA3 adds hepatic lipid export context and should be interpreted with the surrounding pathway pattern, not on its own.
TM6SF2
TM6SF2 adds weight to the same pathway interpretation, but does not drive it alone.
TM6SF2 adds hepatic lipid export context and should be interpreted with the surrounding pathway pattern, not on its own.
MBOAT7
MBOAT7 adds weight to the same pathway interpretation, but does not drive it alone.
MBOAT7 adds hepatic lipid export context and should be interpreted with the surrounding pathway pattern, not on its own.
HSD17B13
HSD17B13 adds weight to the same pathway interpretation, but does not drive it alone.
HSD17B13 adds hepatic lipid export context and should be interpreted with the surrounding pathway pattern, not on its own.
APOA5
APOA5 adds weight to the same pathway interpretation, but does not drive it alone.
APOA5 adds hepatic lipid export context and should be interpreted with the surrounding pathway pattern, not on its own.