What stands out
This pathway matters mainly as supporting context.
Working interpretation
The working read here is lower histamine support.
Key markers
Plasma histamine, DAO activity, tryptase
Priority context
Moderate. It is worth checking if symptoms or existing labs point in the same direction.
Why it rose
Why this pathway surfaced
This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.
Plasma histamine
shows whether histamine burden itself looks elevated
DAO activity
gives context on how well extracellular histamine may be broken down
tryptase
helps show whether mast-cell or allergic activation is part of the picture
Main genes
Which genes are carrying the signal
ALDH2
ALDH2 adds weight to the same pathway interpretation, but does not drive it alone.
ALDH2 adds histamine context and should be interpreted with the surrounding pathway pattern, not on its own.