What stands out
This is a meaningful pathway in the sample.
Working interpretation
The working read here is lower insulin sensitivity support.
Key markers
Fasting insulin, HOMA-IR, C-peptide
Priority context
High. This is one of the clearest and most testable findings in the report.
Why it rose
Why this pathway surfaced
This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.
Fasting insulin
shows how much insulin support the body is using in the fasting state
HOMA-IR
HOMA-IR gives practical context for whether insulin sensitivity is showing up in real physiology.
C-peptide
C-peptide gives practical context for whether insulin sensitivity is showing up in real physiology.
Main genes
Which genes are carrying the signal
INSR
INSR adds weight to the same pathway interpretation, but does not drive it alone.
INSR adds insulin sensitivity context and should be interpreted with the surrounding pathway pattern, not on its own.
IRS2
IRS2 adds weight to the same pathway interpretation, but does not drive it alone.
IRS2 adds insulin sensitivity context and should be interpreted with the surrounding pathway pattern, not on its own.
AKT2
AKT2 adds weight to the same pathway interpretation, but does not drive it alone.
AKT2 adds insulin sensitivity context and should be interpreted with the surrounding pathway pattern, not on its own.
ENPP1
ENPP1 adds weight to the same pathway interpretation, but does not drive it alone.
ENPP1 adds insulin sensitivity context and should be interpreted with the surrounding pathway pattern, not on its own.