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Thyroid hormone conversion in the sample report

This page explains why this pathway rose in the sample report, what it likely means, and what to validate next.

Worth checking now

What stands out

This is the strongest pathway in the sample.

What it likely means

Working interpretation

The working read here is lower thyroid hormone conversion support.

What to check next

Key markers

TSH, Free T4 / Free T3, thyroid antibodies

How much to care

Priority context

High. This is one of the clearest and most testable findings in the report.

Why it rose

Why this pathway surfaced

This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.

6 genes reviewed · 16 variant rows

TSH

shows how strongly the brain is signaling the thyroid system

Free T4 / Free T3

show how much thyroid hormone is available before and after activation

thyroid antibodies

help show whether an immune process may be affecting the thyroid picture

Open report sectionOpen evidence appendixOpen evergreen topic guide

Main genes

Which genes are carrying the signal

DIO2

Supporting contributor · Medium confidence

DIO2 adds weight to the same pathway interpretation, but does not drive it alone.

DIO2 adds thyroid hormone conversion context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

PDE8B

Supporting contributor · Medium confidence

PDE8B adds weight to the same pathway interpretation, but does not drive it alone.

PDE8B adds thyroid hormone conversion context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

FOXE1

Supporting contributor · Medium confidence

FOXE1 adds weight to the same pathway interpretation, but does not drive it alone.

FOXE1 adds thyroid hormone conversion context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

TSHR

Supporting contributor · Medium confidence

TSHR adds weight to the same pathway interpretation, but does not drive it alone.

TSHR adds thyroid hormone conversion context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

PPARGC1A

Supporting contributor · Medium confidence

PPARGC1A adds weight to the same pathway interpretation, but does not drive it alone.

PPARGC1A adds thyroid hormone conversion context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

UCP2

Supporting contributor · Medium confidence

UCP2 adds weight to the same pathway interpretation, but does not drive it alone.

UCP2 adds thyroid hormone conversion context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix