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Primary topic: ADIPOQ metabolism gene

ADIPOQ Gene and Metabolism: What It Means for Your Body

ADIPOQ is relevant when insulin sensitivity and metabolic resilience seem harder to maintain than broad lifestyle advice would predict.

What is the ADIPOQ gene?

ADIPOQ influences adiponectin-related signaling, which helps shape insulin sensitivity, fatty-acid handling, and broader metabolic flexibility.

How ADIPOQ affects metabolism

If ADIPOQ-related signaling is less favorable, the system may become less resilient around insulin response and fat handling. That can make metabolism feel less forgiving under stress or inconsistent habits.

What happens when ADIPOQ is altered

Altered ADIPOQ function does not create a diagnosis on its own, but it can make insulin-sensitivity follow-up more relevant than generic body-composition advice.

Curated SNP evidence for ADIPOQ

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Glucose Lipids Nitric oxide / vascular tone

Evidence-backed report connection

ADIPOQ currently has 2 curated SNPs, 6 claim-level scores, and 0 claims eligible for pathway scoring.

Open the sample report
rs1501299ADIPOQ +276G>T, ADIPOQ supporting signal3 claims · 12 study rows

unknown · GG

ADIPOQ unscored target

Not used for pathway scoring

rs1501299 GG has no scored directional claim for ADIPOQ unscored target.

ADIPOQ rs1501299 has been studied with adiponectin and metabolic markers, but the current evidence is not consistent enough for a directional end-user genotype effect.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs1501299 at the ADIPOQ locus. The commonly reported genotype letters for end-user literature are GG, GT, and TT.PubMed 19755407biomarker association · loose proxyMelistas et al. studied ADIPOQ +276G>T rs1501299 together with rs2241766 in women without diabetes. In single-SNP analysis, rs1501299 related to insulin-resistance measures but not to total or high-molecular-weight adiponectin, and effects varied by body-fat category.PubMed 22748670biomarker association · loose proxyGui et al. studied rs1501299 in coronary artery disease and control participants. They reported more T-containing genotypes in the coronary artery disease group, but did not find a significant correlation between rs1501299 genotype and serum adiponectin levels.PubMed 31002147biomarker association · loose proxyDe Luis et al. studied obese adults during hypocaloric diets and reported improved adiponectin and insulin-resistance measures mainly in GG participants, while GT and TT were combined for analysis. This supports context-specific interest but not a stable standalone genotype direction.

unknown · GT

ADIPOQ unscored target

Not used for pathway scoring

rs1501299 GT has no scored directional claim for ADIPOQ unscored target.

ADIPOQ rs1501299 has been studied with adiponectin and metabolic markers, but the current evidence is not consistent enough for a directional end-user genotype effect.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs1501299 at the ADIPOQ locus. The commonly reported genotype letters for end-user literature are GG, GT, and TT.PubMed 19755407biomarker association · loose proxyMelistas et al. studied ADIPOQ +276G>T rs1501299 together with rs2241766 in women without diabetes. In single-SNP analysis, rs1501299 related to insulin-resistance measures but not to total or high-molecular-weight adiponectin, and effects varied by body-fat category.PubMed 22748670biomarker association · loose proxyGui et al. studied rs1501299 in coronary artery disease and control participants. They reported more T-containing genotypes in the coronary artery disease group, but did not find a significant correlation between rs1501299 genotype and serum adiponectin levels.PubMed 31002147biomarker association · loose proxyDe Luis et al. studied obese adults during hypocaloric diets and reported improved adiponectin and insulin-resistance measures mainly in GG participants, while GT and TT were combined for analysis. This supports context-specific interest but not a stable standalone genotype direction.

unknown · TT

ADIPOQ unscored target

Not used for pathway scoring

rs1501299 TT has no scored directional claim for ADIPOQ unscored target.

ADIPOQ rs1501299 has been studied with adiponectin and metabolic markers, but the current evidence is not consistent enough for a directional end-user genotype effect.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs1501299 at the ADIPOQ locus. The commonly reported genotype letters for end-user literature are GG, GT, and TT.PubMed 19755407biomarker association · loose proxyMelistas et al. studied ADIPOQ +276G>T rs1501299 together with rs2241766 in women without diabetes. In single-SNP analysis, rs1501299 related to insulin-resistance measures but not to total or high-molecular-weight adiponectin, and effects varied by body-fat category.PubMed 22748670biomarker association · loose proxyGui et al. studied rs1501299 in coronary artery disease and control participants. They reported more T-containing genotypes in the coronary artery disease group, but did not find a significant correlation between rs1501299 genotype and serum adiponectin levels.PubMed 31002147biomarker association · loose proxyDe Luis et al. studied obese adults during hypocaloric diets and reported improved adiponectin and insulin-resistance measures mainly in GG participants, while GT and TT were combined for analysis. This supports context-specific interest but not a stable standalone genotype direction.
rs2241766ADIPOQ +45T>G, ADIPOQ supporting signal3 claims · 12 study rows

unknown · GG

ADIPOQ unscored target

Not used for pathway scoring

rs2241766 GG has no scored directional claim for ADIPOQ unscored target.

ADIPOQ rs2241766 has been associated with adiponectin, glycemic, and metabolic-syndrome findings in some settings, but the evidence is too context-dependent for a simple directional end-user effect.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs2241766 at the ADIPOQ locus. The commonly reported genotype letters for end-user literature are GG, GT, and TT.PubMed 19755407biomarker association · loose proxyMelistas et al. studied ADIPOQ +45T>G rs2241766 in women without diabetes. The single-SNP analysis did not show an association with total or high-molecular-weight adiponectin, lipid measures, or body-composition variables.PubMed 35528179biomarker association · loose proxyAlfaqih et al. studied adults with type 2 diabetes and reported that the rs2241766 T allele and TT genotype were more frequent in poor glycemic control and that TT had lower serum adiponectin. This is disease-context evidence rather than a general-population effect.PubMed 27554120review · loose proxyGao et al. meta-analyzed Chinese studies of metabolic syndrome and reported an association for rs2241766, with the G allele increasing metabolic-syndrome risk. This differs by endpoint and population from other adiponectin-focused reports, so a neutral simplified score is used.

unknown · GT

ADIPOQ unscored target

Not used for pathway scoring

rs2241766 GT has no scored directional claim for ADIPOQ unscored target.

ADIPOQ rs2241766 has been associated with adiponectin, glycemic, and metabolic-syndrome findings in some settings, but the evidence is too context-dependent for a simple directional end-user effect.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs2241766 at the ADIPOQ locus. The commonly reported genotype letters for end-user literature are GG, GT, and TT.PubMed 19755407biomarker association · loose proxyMelistas et al. studied ADIPOQ +45T>G rs2241766 in women without diabetes. The single-SNP analysis did not show an association with total or high-molecular-weight adiponectin, lipid measures, or body-composition variables.PubMed 35528179biomarker association · loose proxyAlfaqih et al. studied adults with type 2 diabetes and reported that the rs2241766 T allele and TT genotype were more frequent in poor glycemic control and that TT had lower serum adiponectin. This is disease-context evidence rather than a general-population effect.PubMed 27554120review · loose proxyGao et al. meta-analyzed Chinese studies of metabolic syndrome and reported an association for rs2241766, with the G allele increasing metabolic-syndrome risk. This differs by endpoint and population from other adiponectin-focused reports, so a neutral simplified score is used.

unknown · TT

ADIPOQ unscored target

Not used for pathway scoring

rs2241766 TT has no scored directional claim for ADIPOQ unscored target.

ADIPOQ rs2241766 has been associated with adiponectin, glycemic, and metabolic-syndrome findings in some settings, but the evidence is too context-dependent for a simple directional end-user effect.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs2241766 at the ADIPOQ locus. The commonly reported genotype letters for end-user literature are GG, GT, and TT.PubMed 19755407biomarker association · loose proxyMelistas et al. studied ADIPOQ +45T>G rs2241766 in women without diabetes. The single-SNP analysis did not show an association with total or high-molecular-weight adiponectin, lipid measures, or body-composition variables.PubMed 35528179biomarker association · loose proxyAlfaqih et al. studied adults with type 2 diabetes and reported that the rs2241766 T allele and TT genotype were more frequent in poor glycemic control and that TT had lower serum adiponectin. This is disease-context evidence rather than a general-population effect.PubMed 27554120review · loose proxyGao et al. meta-analyzed Chinese studies of metabolic syndrome and reported an association for rs2241766, with the G allele increasing metabolic-syndrome risk. This differs by endpoint and population from other adiponectin-focused reports, so a neutral simplified score is used.

Common symptoms people report

  • metabolic resilience that feels lower than expected
  • weight and glucose patterns that drift together
  • sluggish response to routine nutrition clean-up
  • concern that insulin sensitivity may not be ideal

Biomarkers to validate

Fasting insulin

Useful for checking whether insulin-related pressure is already visible.

Triglycerides

Adds context when insulin sensitivity and lipid handling overlap.

HbA1c

Helpful for longer-term glucose context.

Where DNA analysis helps

DNA can show whether insulin-sensitivity pathways deserve more attention before generic weight-management advice is treated as enough.

Example Insight

Your insulin-sensitivity pathway may deserve follow-up because adiponectin-related signaling looks less robust than expected.

Suggested validation: fasting insulin and triglycerides.

What to do next

  • Use fasting insulin and triglycerides to check whether the pathway is showing up in practice.
  • Compare ADIPOQ with IRS1 and PPARG when metabolic resilience seems lower than expected.
  • Use the gene as prioritization, not as a conclusion.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

Get My DNA Report

Related pages

IRS1

IRS1 insulin signaling gene

PPARG

PPARG metabolism gene

ApoB

ApoB and lipid risk

Fasting insulin

fasting insulin and metabolism

Glucose regulation pathway

glucose regulation pathway

Lipid transport pathway

lipid transport pathway

Genetic test for weight loss Europe

genetic test for weight loss Europe

Related symptom angle

Insulin resistance genetics

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