Sample report
See how the evidence becomes a pathway report
Open the evidence-backed sample report to see the same pathway, gene, and SNP concepts turned into a customer-facing result.
Topic hubs
Topic Guides
14 results
B12 transport
B12 transport DNA analysis
B12 transport becomes important when intake looks reasonable but functional support still looks uneven. DNA helps most when it shows whether transport and recycling deserve their own follow-up instead of being hidden inside broader methylation discussion.
Caffeine / stimulant sensitivity
caffeine sensitivity DNA analysis
Caffeine response can be a real pattern, not just a personality quirk. DNA can help separate slower clearance from stronger receptor sensitivity.
Choline support
choline support DNA analysis
Choline support sits at the overlap of phosphatidylcholine production, liver support, lipid handling, and methyl-donor demand. DNA helps most when it clarifies whether that overlap deserves real follow-up rather than generic nutrition advice.
Estrogen metabolism
estrogen metabolism DNA analysis
Estrogen handling sits at the overlap of methylation, detox support, and hormone clearance. The point is to decide whether clearance deserves separate follow-up.
Glucose
glucose regulation DNA analysis
Glucose regulation is not just about blood sugar. It also reflects insulin signaling, meal response, energy handling, and recovery under load. DNA can help prioritize which parts of that system may deserve deeper follow-up.
Histamine
histamine genetics metabolism
Histamine problems rarely come from a single input. Diet, gut context, methylation support, and clearance genes can all contribute. DNA helps most when it clarifies which clearance mechanisms deserve closer follow-up.
Inflammation / immune signaling
inflammation DNA analysis
Inflammation changes the behavior of many other pathways. The useful question is whether immune tone deserves to move into the main decision layer.
Iron handling
iron handling DNA analysis
Iron status becomes harder to interpret when storage, transport, and inflammation overlap.
Lipids
lipid metabolism DNA analysis
Lipid handling covers transport, storage, oxidation, and how your body responds to dietary fat. DNA can help identify where lipid-related systems may need more structured follow-up than generic cholesterol advice provides.
Methylation
methylation DNA analysis
Methylation sits at the center of folate handling, homocysteine recycling, neurotransmitter support, and many day-to-day cellular processes. The useful question is not whether methylation matters. It is which parts of the system may actually deserve validation first.
Mitochondrial energy
mitochondrial energy DNA analysis
Mitochondrial throughput is a better explanation for some fatigue patterns than generic oxidative stress or motivation language.
Nitric oxide / vascular tone
nitric oxide DNA analysis
Circulation and endothelial support can matter more than people expect in energy, exercise, and recovery questions.
Oxidative stress
oxidative stress DNA analysis
Oxidative stress is one of the most common ways people experience system load without clear explanation. DNA can help show where buffering capacity may be weaker and which validation markers could make that signal more concrete.
Sulfur / transsulfuration
sulfur transsulfuration DNA analysis
Sulfur flow sits between methylation, glutathione support, and detox resilience. The useful question is whether downstream sulfur handling deserves its own follow-up instead of staying buried inside methylation talk.
Genes
Gene Guides
171 results
ABCA1
ABCA1 cholesterol efflux gene
ABCA1 supports cholesterol efflux and early HDL particle formation.
ABCC8
ABCC8 gene blood-sugar regulation
ABCC8 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
ABCG8
ABCG8 sterol transport gene
ABCG8 helps move sterols through intestinal and biliary transport routes, which can affect LDL-C and cholesterol absorption context.
ACADM
ACADM gene cellular energy production
ACADM is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
ACADS
ACADS gene cellular energy production
ACADS is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 2 SNPs and 2 curated claims.
ACADVL
ACADVL gene cellular energy production
ACADVL is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
ACAT1
ACAT1 gene cellular energy production
ACAT1 is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 2 SNPs and 2 curated claims.
ADIPOQ
ADIPOQ metabolism gene
ADIPOQ is relevant when insulin sensitivity and metabolic resilience seem harder to maintain than broad lifestyle advice would predict.
ADORA2A
ADORA2A gene DNA analysis
ADORA2A becomes more useful when caffeine / stimulant sensitivity looks like a meaningful follow-up area instead of just background context.
AGL
AGL gene blood-sugar regulation
AGL is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
AGXT2
AGXT2 gene blood-vessel tone and nitric-oxide context
AGXT2 is tracked because it connects to vascular relaxation, methylarginine handling, or blood-pressure response under stress. The current evidence index links this gene to Nitric oxide / vascular tone with 1 SNP and 1 curated claim.
AHR
AHR gene DNA analysis
AHR becomes more useful when caffeine / stimulant sensitivity looks like a meaningful follow-up area instead of just background context.
ALDH2
ALDH2 aldehyde clearance gene
ALDH2 matters when aldehyde load, alcohol sensitivity, and histamine-like reactions overlap.
ALDOB
ALDOB gene blood-sugar regulation
ALDOB is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
AMPD1
AMPD1 gene cellular energy production
AMPD1 is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
AMY1
AMY1 starch digestion gene
AMY1 is relevant when carbohydrate tolerance seems unusually variable, especially with starch-heavy meals.
ANGPTL4
ANGPTL4 gene cholesterol and blood-fat handling
ANGPTL4 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
AOC1
AOC1 histamine clearance gene
AOC1 becomes relevant when histamine-clearance capacity looks weaker than symptom tracking alone can explain.
APOA1
APOA1 gene cholesterol and blood-fat handling
APOA1 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
APOA5
APOA5 triglyceride gene
APOA5 matters when triglycerides look more central than cholesterol alone in the lipid picture.
APOB
APOB gene cholesterol and blood-fat handling
APOB is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
APOC3
APOC3 gene cholesterol and blood-fat handling
APOC3 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 2 SNPs and 2 curated claims.
APOE
APOE gene metabolism
APOE is important for lipid transport and how fats are packaged and moved through the body, making it relevant to cholesterol and metabolic resilience.
ARG1
ARG1 gene DNA analysis
ARG1 becomes more useful when nitric oxide / vascular tone looks like a meaningful follow-up area instead of just background context.
BCAM
BCAM gene choline and methyl-donor support
BCAM is tracked because it connects to choline intake need, phosphatidylcholine support, liver fat handling, or methyl-donor backup. The current evidence index links this gene to Choline support with 1 SNP and 6 curated claims.
BHMT
BHMT gene function
BHMT is one of the key backup remethylation routes for homocysteine handling, making it important when methylation support and choline-derived methyl donors are under pressure.
CAT
CAT antioxidant gene
CAT matters when peroxide buffering may be weaker than workload and recovery demands require.
CBS
CBS gene methylation
CBS sits at the point where homocysteine can move out of remethylation and into the transsulfuration pathway, linking methylation balance with sulfur metabolism.
CETP
CETP lipid transport gene
CETP matters when lipoprotein exchange and HDL-triglyceride context deserve more attention than total cholesterol alone.
CHDH
CHDH choline oxidation gene
CHDH matters when choline handling and betaine support may be part of the same methyl-donor problem.
COMT
COMT gene metabolism
COMT helps break down catecholamines and methylated compounds, which places it at the intersection of neurotransmitter handling and methylation demand.
CPT1A
CPT1A gene cellular energy production
CPT1A is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
CPT2
CPT2 gene cellular energy production
CPT2 is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 2 SNPs and 2 curated claims.
CRP
CRP gene DNA analysis
CRP becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area instead of just background context.
CTH
CTH gene DNA analysis
CTH becomes more useful when sulfur / transsulfuration looks like a meaningful follow-up area instead of just background context.
CUBN
CUBN B12 absorption gene
CUBN matters when B12 availability may be limited before transport and recycling even begin.
CYBA
CYBA gene stress recovery and antioxidant defense
CYBA is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
CYP1A1
CYP1A1 gene DNA analysis
CYP1A1 becomes more useful when estrogen metabolism looks like a meaningful follow-up area instead of just background context.
CYP1A2
CYP1A2 gene DNA analysis
CYP1A2 becomes more useful when caffeine and stimulant sensitivity looks like a meaningful follow-up area instead of just a lifestyle footnote.
CYP1A2
CYP1A2 caffeine metabolism gene
CYP1A2 is the gene most people encounter first when they ask why caffeine hits them harder or lasts longer than expected.
CYP1B1
CYP1B1 gene DNA analysis
CYP1B1 becomes more useful when estrogen metabolism looks like a meaningful follow-up area instead of just background context.
CYP2C19
CYP2C19 metabolism gene
CYP2C19 is another compound-metabolism gene that becomes important when drug handling or unusual response patterns keep showing up.
CYP2D6
CYP2D6 drug metabolism gene
CYP2D6 is best known for medication metabolism, but it also matters more broadly wherever compound clearance differences make people respond unpredictably.
CYP3A4
CYP3A4 gene steroid hormone processing
CYP3A4 is tracked because it connects to estrogen-like hormone clearance, steroid bioavailability, and liver phase-I or phase-Ii context. The current evidence index links this gene to Estrogen metabolism with 1 SNP and 1 curated claim.
CYP3A5
CYP3A5 gene steroid hormone processing
CYP3A5 is tracked because it connects to estrogen-like hormone clearance, steroid bioavailability, and liver phase-I or phase-Ii context. The current evidence index links this gene to Estrogen metabolism with 1 SNP and 1 curated claim.
DAO
DAO gene histamine metabolism
DAO is one of the main histamine-clearance genes people look at when food-triggered symptoms, flushing, or unpredictable reactivity show up.
DLD
DLD gene cellular energy production
DLD is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
DMGDH
DMGDH gene methylation and B-vitamin use
DMGDH is tracked because it connects to homocysteine handling, folate use, and one-carbon metabolism. The current evidence index links this gene to Methylation with 1 SNP and 1 curated claim.
ELOVL2
ELOVL2 gene cholesterol and blood-fat handling
ELOVL2 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
ENPP1
ENPP1 gene blood-sugar regulation
ENPP1 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
ETFDH
ETFDH gene cellular energy production
ETFDH is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
FBP1
FBP1 gene blood-sugar regulation
FBP1 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 2 SNPs and 2 curated claims.
FOXO3
FOXO3 gene immune alarm and inflammatory signaling
FOXO3 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
FTO
FTO gene weight gain
FTO is commonly discussed in weight-gain genetics because it can influence appetite regulation, energy intake, and how strongly food cues affect behavior.
FUT2
FUT2 gene gut microbiome
FUT2 shapes how certain glycans are expressed in the gut environment, which can influence microbiome behavior and downstream nutrient handling.
G6PC1
G6PC1 gene blood-sugar regulation
G6PC1 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 2 SNPs and 2 curated claims.
G6PC2
G6PC2 gene blood-sugar regulation
G6PC2 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
G6PD
G6PD deficiency metabolism
G6PD is central to redox defense because it supports NADPH generation, which cells use to maintain antioxidant capacity.
GBA1
GBA1 gene cholesterol and blood-fat handling
GBA1 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
GCDH
GCDH gene cellular energy production
GCDH is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
GCH1
GCH1 gene DNA analysis
GCH1 becomes more useful when nitric oxide / vascular tone looks like a meaningful follow-up area instead of just background context.
GCKR
GCKR glucose liver gene
GCKR becomes relevant when glucose handling and liver-driven triglyceride patterns overlap.
GCLC
GCLC glutathione synthesis gene
GCLC matters when glutathione supply itself may be part of the oxidative-stress problem.
GIPR
GIPR gene blood-sugar regulation
GIPR is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
GLP1R
GLP1R gene blood-sugar regulation
GLP1R is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
GPX1
GPX1 antioxidant gene
GPX1 is part of the glutathione-based antioxidant system and becomes relevant when oxidative buffering may be a real bottleneck.
GPX4
GPX4 gene stress recovery and antioxidant defense
GPX4 is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
GSS
GSS gene DNA analysis
GSS becomes more useful when sulfur / transsulfuration looks like a meaningful follow-up area instead of just background context.
GSTA1
GSTA1 gene stress recovery and antioxidant defense
GSTA1 is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
GSTM1
GSTM1 detox redox gene
GSTM1 becomes relevant when glutathione-linked detox support and oxidative reserve may be part of the same problem.
GYS2
GYS2 gene blood-sugar regulation
GYS2 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
HADHA
HADHA gene cellular energy production
HADHA is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
HAMP
HAMP gene iron absorption, storage, and release
HAMP is tracked because it connects to hepcidin signaling, iron export, and whether iron tends to accumulate or run low. The current evidence index links this gene to Iron handling with 2 SNPs and 2 curated claims.
HDC
HDC histamine production gene
HDC matters when histamine production itself may be part of the problem rather than only clearance.
HFE
HFE gene DNA analysis
HFE becomes more useful when iron handling looks like a meaningful follow-up area instead of just background context.
HJV
HJV gene iron absorption, storage, and release
HJV is tracked because it connects to hepcidin signaling, iron export, and whether iron tends to accumulate or run low. The current evidence index links this gene to Iron handling with 1 SNP and 1 curated claim.
HLA-DQA1
HLA-DQA1 celiac immune risk
HLA-DQA1 helps form HLA-DQ molecules that can present gluten peptides in celiac-compatible immune backgrounds.
HLA-DQB1
HLA-DQB1 celiac immune risk
HLA-DQB1 helps form HLA-DQ beta chains used in DQ2, DQ8, and related celiac-compatible antigen-presentation backgrounds.
HLA-DRA
HLA-DRA DQ2.2 celiac tag
HLA-DRA-region markers can contribute to HLA-DQ2.2 tag patterns, but single markers should not be interpreted alone.
HMGCL
HMGCL gene cellular energy production
HMGCL is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
HMGCR
HMGCR gene cholesterol and blood-fat handling
HMGCR is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
HNMT
HNMT gene histamine metabolism
HNMT handles histamine inside cells, making it relevant when histamine patterns look broader than just food reactions.
HSD17B13
HSD17B13 gene cholesterol and blood-fat handling
HSD17B13 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
IL1RN
IL1RN gene immune alarm and inflammatory signaling
IL1RN is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
IL6
IL6 gene DNA analysis
IL6 becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area instead of just background context.
IL6R
IL6R gene immune alarm and inflammatory signaling
IL6R is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
IRS1
IRS1 insulin signaling gene
IRS1 sits close to the center of insulin signaling, making it highly relevant when carb response and metabolic flexibility are in question.
KCNJ11
KCNJ11 insulin secretion gene
KCNJ11 is relevant when the gating of insulin release may be part of the glucose-regulation picture.
KLKB1
KLKB1 gene immune alarm and inflammatory signaling
KLKB1 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
LCAT
LCAT gene cholesterol and blood-fat handling
LCAT is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
LCT
LCT gene lactose digestion
LCT encodes lactase, the enzyme that breaks lactose in dairy into absorbable sugars.
LDLR
LDLR cholesterol clearance gene
LDLR matters when LDL clearance rather than only production seems relevant to the lipid picture.
LEPR
LEPR leptin resistance gene
LEPR becomes relevant when satiety signals feel unreliable and weight regulation seems harder than generic advice would predict.
LIPC
LIPC gene cholesterol and blood-fat handling
LIPC is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
LIPG
LIPG gene cholesterol and blood-fat handling
LIPG is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
LPA
LPA gene cholesterol and blood-fat handling
LPA is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 2 SNPs and 2 curated claims.
LPIN1
LPIN1 gene cholesterol and blood-fat handling
LPIN1 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
LPL
LPL triglyceride clearance gene
LPL becomes important when triglyceride clearance and fat handling look like the real lipid bottleneck.
MAOA
MAOA gene metabolism
MAOA helps break down monoamine neurotransmitters and is relevant when catecholamine balance, mood stability, or stress recovery seem unusually sensitive.
MAT1A
MAT1A methyl donor gene
MAT1A matters when methyl-donor supply itself looks like a bottleneck rather than only folate or B12 handling.
MBL2
MBL2 gene immune alarm and inflammatory signaling
MBL2 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
MCM6
MCM6 LCT enhancer lactase persistence
MCM6 contains regulatory enhancer markers that influence adult LCT expression and lactase persistence.
MLXIPL
MLXIPL gene cholesterol and blood-fat handling
MLXIPL is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
MMACHC
MMACHC gene B12 transport and cellular use
MMACHC is tracked because it connects to B12 delivery, intracellular cobalamin processing, and methylation support. The current evidence index links this gene to B12 transport with 4 SNPs and 4 curated claims.
MTARC1
MTARC1 gene cholesterol and blood-fat handling
MTARC1 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
MTHFD1
MTHFD1 gene methylation and B-vitamin use
MTHFD1 is tracked because it connects to homocysteine handling, folate use, and one-carbon metabolism. The current evidence index links this gene to Methylation with 1 SNP and 1 curated claim.
MTHFR
MTHFR gene metabolism
MTHFR sits inside the folate cycle and helps produce methyl groups used across detoxification, neurotransmitter balance, and homocysteine handling.
MTNR1B
MTNR1B glucose circadian gene
MTNR1B becomes relevant when fasting glucose and circadian timing seem more connected than expected.
MTR
MTR methionine synthase gene
MTR matters when the final B12-dependent remethylation step looks less reliable than expected.
MTRR
MTRR B12 recycling gene
MTRR supports B12 recycling inside the methylation network, so it matters when homocysteine or functional B12 questions do not line up cleanly with diet alone.
NAT2
NAT2 slow acetylator gene
NAT2 is a classic detoxification pathway gene that affects how quickly certain compounds are acetylated and cleared.
NCF2
NCF2 celiac gene
NCF2 is tracked as a small-effect non-HLA immune susceptibility locus in celiac GWAS evidence.
NDUFS7
NDUFS7 gene DNA analysis
NDUFS7 becomes more useful when mitochondrial energy looks like a meaningful follow-up area instead of just background context.
NFE2L2
NFE2L2 gene stress recovery and antioxidant defense
NFE2L2 is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
NFKB1
NFKB1 gene DNA analysis
NFKB1 becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area instead of just background context.
NLRP3
NLRP3 gene immune alarm and inflammatory signaling
NLRP3 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 2 SNPs and 2 curated claims.
NOS3
NOS3 nitric oxide gene
NOS3 is relevant when circulation, endothelial function, and nitric-oxide-related performance response seem harder to optimize than expected.
NQO1
NQO1 redox defense gene
NQO1 matters when oxidative load and detoxification overlap in a way that feels harder to recover from.
P2RX7
P2RX7 gene immune alarm and inflammatory signaling
P2RX7 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
PCSK9
PCSK9 LDL regulation gene
PCSK9 helps regulate how many LDL receptors remain available to clear LDL particles from circulation.
PEMT
PEMT gene choline metabolism
PEMT is relevant for choline handling and phosphatidylcholine synthesis, which matter for liver function, membrane integrity, and methylation-related support.
PGM1
PGM1 gene blood-sugar regulation
PGM1 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
PNPLA3
PNPLA3 gene cholesterol and blood-fat handling
PNPLA3 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
PON1
PON1 gene stress recovery and antioxidant defense
PON1 is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
POR
POR caffeine metabolism gene
POR is tracked as supporting context for cytochrome P450 enzyme activity, including caffeine-metabolism biology.
PPARA
PPARA fat metabolism gene
PPARA helps regulate fat oxidation, especially when the body is shifting toward using stored fat for energy.
PPARG
PPARG metabolism gene
PPARG influences adipose biology and insulin sensitivity, making it relevant to how energy is stored and how tissues respond to glucose-related signals.
PPARGC1A
PPARGC1A gene DNA analysis
PPARGC1A becomes more useful when mitochondrial energy looks like a meaningful follow-up area instead of just background context.
PUS10
PUS10 celiac Crohn immune locus
PUS10 is tracked as a small-effect non-HLA immune susceptibility locus reported in combined celiac and Crohn genetics.
PYGL
PYGL gene blood-sugar regulation
PYGL is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
SERPING1
SERPING1 gene immune alarm and inflammatory signaling
SERPING1 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
SH2B3
SH2B3 celiac gene
SH2B3 is tracked as small-effect immune signaling context in celiac GWAS evidence.
SHMT1
SHMT1 gene metabolism
SHMT1 participates in one-carbon metabolism and helps move folate-related chemistry toward processes that support methylation and nucleotide balance.
SLC19A1
SLC19A1 folate transport gene
SLC19A1 becomes relevant when folate availability looks less reliable than intake alone would suggest.
SLC22A1
SLC22A1 gene blood-sugar regulation
SLC22A1 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 2 SNPs and 2 curated claims.
SLC22A5
SLC22A5 gene cellular energy production
SLC22A5 is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 5 SNPs and 5 curated claims.
SLC23A1
SLC23A1 gene stress recovery and antioxidant defense
SLC23A1 is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
SLC25A13
SLC25A13 gene cellular energy production
SLC25A13 is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 1 SNP and 1 curated claim.
SLC25A20
SLC25A20 gene cellular energy production
SLC25A20 is tracked because it connects to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. The current evidence index links this gene to Mitochondrial energy with 4 SNPs and 4 curated claims.
SLC2A1
SLC2A1 gene blood-sugar regulation
SLC2A1 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
SLC2A2
SLC2A2 gene blood-sugar regulation
SLC2A2 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 3 SNPs and 3 curated claims.
SLC30A8
SLC30A8 insulin gene
SLC30A8 matters when insulin secretion quality itself looks like part of the glucose-handling picture.
SLC37A4
SLC37A4 gene blood-sugar regulation
SLC37A4 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
SLC40A1
SLC40A1 gene iron absorption, storage, and release
SLC40A1 is tracked because it connects to hepcidin signaling, iron export, and whether iron tends to accumulate or run low. The current evidence index links this gene to Iron handling with 1 SNP and 1 curated claim.
SLC44A1
SLC44A1 choline transporter gene
SLC44A1 matters when choline delivery itself may be part of the membrane and methyl-donor picture.
SLC46A1
SLC46A1 gene methylation and B-vitamin use
SLC46A1 is tracked because it connects to homocysteine handling, folate use, and one-carbon metabolism. The current evidence index links this gene to Methylation with 4 SNPs and 4 curated claims.
SLC5A2
SLC5A2 gene blood-sugar regulation
SLC5A2 is tracked because it connects to meal response, fasting glucose control, insulin signaling, or glucose transport. The current evidence index links this gene to Glucose with 1 SNP and 1 curated claim.
SLC6A4
SLC6A4 serotonin metabolism gene
SLC6A4 affects serotonin transport and is relevant when neurotransmitter handling, stress response, and gut-brain signaling seem unusually sensitive.
SLCO1B1
SLCO1B1 gene cholesterol and blood-fat handling
SLCO1B1 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
SOD2
SOD2 oxidative stress gene
SOD2 supports mitochondrial antioxidant defense, making it relevant when recovery and oxidative load seem harder than expected.
SOD3
SOD3 gene stress recovery and antioxidant defense
SOD3 is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
SORT1
SORT1 gene cholesterol and blood-fat handling
SORT1 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
SULT1A1
SULT1A1 gene DNA analysis
SULT1A1 becomes more useful when estrogen metabolism looks like a meaningful follow-up area instead of just background context.
SUOX
SUOX gene DNA analysis
SUOX becomes more useful when sulfur / transsulfuration looks like a meaningful follow-up area instead of just background context.
TCF7L2
TCF7L2 diabetes gene
TCF7L2 is one of the better-known glucose-related genes and becomes relevant when insulin and carb-response questions need clearer prioritization.
TCN1
TCN1 B12 carrier gene
TCN1 is tracked as circulating B12 carrier context, not as the main cellular B12 delivery route.
TCN2
TCN2 B12 transport gene
TCN2 helps move vitamin B12 into tissues, so it matters when methylation support looks weak despite reasonable B12 intake.
TF
TF gene DNA analysis
TF becomes more useful when iron handling looks like a meaningful follow-up area instead of just background context.
TFR2
TFR2 gene DNA analysis
TFR2 becomes more useful when iron handling looks like a meaningful follow-up area instead of just background context.
TLR1
TLR1 gene immune alarm and inflammatory signaling
TLR1 is tracked because it connects to cytokine signaling, inflammasome tone, complement activity, or inflammatory resolution. The current evidence index links this gene to Inflammation / immune signaling with 1 SNP and 1 curated claim.
TM6SF2
TM6SF2 gene cholesterol and blood-fat handling
TM6SF2 is tracked because it connects to lipoprotein transport, triglyceride-rich particles, LDL clearance, or liver lipid handling. The current evidence index links this gene to Lipids with 1 SNP and 1 curated claim.
TMPRSS6
TMPRSS6 gene DNA analysis
TMPRSS6 becomes more useful when iron handling looks like a meaningful follow-up area instead of just background context.
TNFA
TNFA gene DNA analysis
TNFA becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area instead of just background context.
TNFAIP3
TNFAIP3 celiac immune gene
TNFAIP3 is tracked as small-effect non-HLA immune susceptibility context for celiac risk.
TRIB1
TRIB1 lipid gene
TRIB1 is tracked as liver lipid-regulation context, especially around triglyceride-rich and apoB-containing particles.
TTPA
TTPA gene stress recovery and antioxidant defense
TTPA is tracked because it connects to redox buffering, oxidative workload, and recovery after sleep loss, illness, alcohol, or hard training. The current evidence index links this gene to Oxidative stress with 1 SNP and 1 curated claim.
UCP2
UCP2 gene DNA analysis
UCP2 becomes more useful when mitochondrial energy looks like a meaningful follow-up area instead of just background context.
UGT1A1
UGT1A1 detox gene
UGT1A1 is part of the conjugation system that helps package compounds for clearance, including bilirubin and various metabolic byproducts.
UGT1A4
UGT1A4 gene steroid hormone processing
UGT1A4 is tracked because it connects to estrogen-like hormone clearance, steroid bioavailability, and liver phase-I or phase-Ii context. The current evidence index links this gene to Estrogen metabolism with 1 SNP and 1 curated claim.
UGT2B15
UGT2B15 gene steroid hormone processing
UGT2B15 is tracked because it connects to estrogen-like hormone clearance, steroid bioavailability, and liver phase-I or phase-Ii context. The current evidence index links this gene to Estrogen metabolism with 1 SNP and 1 curated claim.
ZMIZ1
ZMIZ1 celiac gene
ZMIZ1 is tracked as a small-effect non-HLA celiac susceptibility locus.
Biomarkers
Biomarker Guides
26 results
ApoB
ApoB and lipid risk
ApoB is a practical lipid marker when DNA points toward transport, packaging, or cholesterol-related follow-up.
Arginine, citrulline, and nitric oxide
Arginine, citrulline, and nitric oxide DNA follow-up
Arginine, citrulline, and nitric oxide becomes more useful when nitric oxide / vascular tone looks like a meaningful follow-up area rather than a vague background topic.
Blood pressure and endothelial context
Blood pressure and endothelial context DNA follow-up
Blood pressure and endothelial context becomes more useful when nitric oxide / vascular tone looks like a meaningful follow-up area rather than a vague background topic.
Caffeine clearance and response
Caffeine clearance and response DNA follow-up
Caffeine clearance and response becomes more useful when caffeine / stimulant sensitivity looks like a meaningful follow-up area rather than a vague background topic.
Choline status
choline status and methyl donor support
Choline-status follow-up becomes useful when membrane support, liver support, and methyl-donor demand appear to overlap.
Cysteine, sulfate, and transsulfuration
Cysteine, sulfate, and transsulfuration DNA follow-up
Cysteine, sulfate, and transsulfuration becomes more useful when sulfur / transsulfuration looks like a meaningful follow-up area rather than a vague background topic.
DAO activity
DAO activity and histamine clearance
DAO activity is one of the clearest ways to validate whether histamine clearance deserves closer attention.
Estrogen metabolites and clearance
Estrogen metabolites and clearance DNA follow-up
Estrogen metabolites and clearance becomes more useful when estrogen metabolism looks like a meaningful follow-up area rather than a vague background topic.
Fasting insulin
fasting insulin and metabolism
Fasting insulin is one of the most useful validation markers when weight, appetite, or carb-response symptoms keep showing up.
Ferritin and inflammatory context
Ferritin and inflammatory context DNA follow-up
Ferritin and inflammatory context becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area rather than a vague background topic.
Ferritin and iron storage
Ferritin and iron storage DNA follow-up
Ferritin and iron storage becomes more useful when iron handling looks like a meaningful follow-up area rather than a vague background topic.
GSH/GSSG ratio
GSH GSSG ratio explained
The GSH/GSSG ratio is a direct way to think about oxidative-stress buffering rather than treating antioxidant support as guesswork.
Holotranscobalamin
holotranscobalamin and B12 transport
Holotranscobalamin is one of the most useful markers when the question is biologically available B12 rather than total intake alone.
Homocysteine
homocysteine and methylation
Homocysteine is one of the simplest ways to check whether methylation support may be under pressure in practice.
Homocysteine and sulfur flow
Homocysteine and sulfur flow DNA follow-up
Homocysteine and sulfur flow becomes more useful when sulfur / transsulfuration looks like a meaningful follow-up area rather than a vague background topic.
hsCRP and inflammatory load
hsCRP and inflammatory load DNA follow-up
hsCRP and inflammatory load becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area rather than a vague background topic.
Iron saturation and CBC context
Iron saturation and CBC context DNA follow-up
Iron saturation and CBC context becomes more useful when iron handling looks like a meaningful follow-up area rather than a vague background topic.
Lactate, pyruvate, and mitochondrial load
Lactate, pyruvate, and mitochondrial load DNA follow-up
Lactate, pyruvate, and mitochondrial load becomes more useful when mitochondrial energy looks like a meaningful follow-up area rather than a vague background topic.
Liver enzymes
liver enzymes and choline support
Liver enzymes are useful when choline-support questions overlap with lipid handling and broader hepatic stress.
Methylmalonic acid
methylmalonic acid and B12
Methylmalonic acid is useful when serum B12 looks inconclusive but functional B12 support still seems questionable.
Organic acids and energy production
Organic acids and energy production DNA follow-up
Organic acids and energy production becomes more useful when mitochondrial energy looks like a meaningful follow-up area rather than a vague background topic.
Oxidative stress panel
oxidative stress panel and redox load
A broader oxidative stress panel helps when glutathione balance alone is not enough to tell you whether redox pressure is real.
SHBG and hormone context
SHBG and hormone context DNA follow-up
SHBG and hormone context becomes more useful when estrogen metabolism looks like a meaningful follow-up area rather than a vague background topic.
Sleep disruption and stimulant load
Sleep disruption and stimulant load DNA follow-up
Sleep disruption and stimulant load becomes more useful when caffeine / stimulant sensitivity looks like a meaningful follow-up area rather than a vague background topic.
Triglycerides
triglycerides and metabolic health
Triglycerides are one of the simplest markers for checking whether energy handling and lipid transport are moving in the right direction.
Tryptase
tryptase and histamine context
Tryptase is useful when you need more mast-cell context around a histamine-style symptom pattern.
Pathways
Pathway Guides
16 results
B12 transport and recycling pathway
B12 transport and recycling pathway
This pathway matters when B12 intake looks acceptable on paper but functional support still looks weak, uneven, or harder to explain.
Caffeine and stimulant sensitivity pathway
caffeine stimulant sensitivity pathway
This pathway matters when caffeine feels unpredictable enough that timing, dose, and sleep disruption all become part of the same question.
Choline and phosphatidylcholine pathway
choline and phosphatidylcholine pathway
This pathway becomes relevant when nutrient tolerance, methylation demand, and membrane-related lipid support seem harder than expected.
Estrogen metabolism and clearance pathway
estrogen metabolism clearance pathway
This pathway matters when hormone handling, methylation, and detox-style questions overlap in a way that generic supplement advice cannot sort out.
Glucose regulation pathway
glucose regulation pathway
Glucose regulation explains much of the difference in carb tolerance, weight gain pressure, and post-meal energy crashes.
Gluten and celiac immune risk pathway
gluten celiac immune risk pathway
This pathway is about celiac-compatible immune background, especially HLA-DQ antigen presentation. It is not a standalone gluten intolerance test.
Histamine clearance pathway
histamine clearance pathway
Histamine symptoms are often treated as food intolerance alone, but the deeper issue is usually how well the body clears histamine under load.
Inflammation and immune signaling pathway
inflammation immune signaling pathway
This pathway matters when recovery, histamine, fatigue, or redox issues all seem to worsen under the same inflammatory load.
Iron handling and storage pathway
iron handling storage pathway
This pathway matters when fatigue, ferritin, and inflammation overlap enough that storage and transport need to be interpreted together.
Lactose digestion pathway
lactose digestion genetics pathway
This pathway focuses on adult lactase expression, the main genetic factor behind whether lactose digestion tends to persist after childhood.
Lipid transport pathway
lipid transport pathway
Lipid transport is not just about total cholesterol. It is about how fat and cholesterol are packaged, moved, and monitored across the system.
Methylation pathway
methylation pathway explained
Methylation is one of the most commonly discussed systems in DNA interpretation because it connects folate, B12, neurotransmitters, detoxification, and homocysteine recycling.
Mitochondrial energy and recovery pathway
mitochondrial energy recovery pathway
This pathway matters when fatigue and recovery problems feel real but still look too diffuse when everything gets labeled as oxidative stress.
Nitric oxide and vascular tone pathway
nitric oxide vascular tone pathway
This pathway matters when circulation, exercise tolerance, and recovery questions keep resurfacing without a clean explanation.
Oxidative stress defense pathway
oxidative stress defense pathway
Oxidative stress is often treated as vague wellness language, but redox defense is a real system that can become a limiting factor under load.
Sulfur and transsulfuration pathway
sulfur transsulfuration pathway
This pathway matters when homocysteine starts the conversation but downstream sulfur handling may be the real bottleneck.
Symptoms
Symptom Guides
10 results
Brain fog
brain fog metabolism causes
Brain fog is often multi-factorial. It can involve methylation support, neurotransmitter balance, histamine handling, nutrient transport, or glucose instability.
Fatigue after eating carbs
fatigue after eating carbs
Feeling tired after carbohydrate-heavy meals usually points to a glucose-regulation or meal-response issue, not simply a lack of willpower.
Histamine intolerance
histamine intolerance genetics
Histamine-related symptoms are often messy because food triggers, gut state, methylation support, and stress load can all play a role at the same time.
Insulin resistance
insulin resistance genetics
Insulin resistance is shaped by lifestyle, but also by how appetite, glucose handling, and fat storage systems interact over time.
Low energy
low energy metabolism causes
Low energy can come from several metabolic bottlenecks: nutrient transport, methylation support, oxidative stress handling, or glucose instability.
Poor detoxification
poor detoxification symptoms
“Poor detoxification” is often used too loosely. The useful question is which specific clearance systems may be under more pressure than expected.
Slow metabolism
slow metabolism genetics
“Slow metabolism” is often used as a catch-all, but the real issue is usually specific systems operating with less efficiency than expected.
Why caffeine hits me hard
why caffeine hits me hard genetics
Caffeine sensitivity is one of the clearest examples of a real-world pathway question that DNA can help prioritize.
Why do I gain weight easily?
why do I gain weight easily genetics
Easy weight gain is usually not explained by one factor. Appetite regulation, glucose handling, satiety signals, and dietary response can all create more friction than generic advice accounts for.
Why supplements do not work for me
why supplements do not work for me
Poor supplement response often means the issue is not the supplement itself, but whether the underlying pathway can absorb, transport, activate, or use it effectively.
Buyer intent
Buyer Guides
9 results
23andMe vs Metastate metabolism report
23andMe vs Metastate metabolism report
23andMe gives you raw DNA data and some standard trait reporting. Metastate is the interpretation layer that turns raw data into pathway-level metabolic priorities.
Analyze 23andMe raw data for metabolism
analyze 23andMe raw data metabolism
Raw DNA exports contain useful information, but they are not actionable on their own. The value comes from translating variant data into metabolic systems that may deserve follow-up.
Best DNA test for metabolism
best DNA test for metabolism
The best DNA test for metabolism is not the one with the most SNPs. It is the one that translates raw data into clear biological priorities and next steps.
DNA nutrition analysis report
DNA nutrition analysis report
A useful DNA nutrition analysis report should not just tell you which nutrients are fashionable. It should show which metabolic systems may affect how you respond to nutrition in the first place.
Generic DNA report vs pathway analysis
generic DNA report vs pathway analysis
The difference is simple: a generic DNA report lists findings, while pathway analysis helps you decide what matters first.
Genetic test for weight loss Europe
genetic test for weight loss Europe
If you are looking for a weight-loss-related DNA report in Europe, the useful question is not whether a gene can predict your body weight. It is which metabolic systems may be making progress harder than it should be.
Nutrigenomics vs metabolic pathway analysis
nutrigenomics vs metabolic pathway analysis
Nutrigenomics often focuses on food-response summaries. Metabolic pathway analysis focuses on the systems underneath those responses and what should be validated next.
Personalized metabolism report online
personalized metabolism report online
If you want a personalized metabolism report online, the useful distinction is between a report that looks personalized and one that actually prioritizes biological systems worth validating.
Upload DNA for health report
upload DNA for health report
If you already have a raw DNA file, the next useful step is not another generic wellness summary. It is a report that prioritizes which metabolic systems may be worth validating first.
Common questions
Question Guides
4 results
Can DNA predict metabolism?
can DNA predict metabolism
DNA can point toward metabolic tendencies, but it does not deliver certainty. The useful question is whether your genes indicate pathways that may deserve more attention, not whether they can predict your whole metabolism by themselves.
How accurate are DNA metabolism reports?
how accurate are DNA metabolism reports
The accuracy of a DNA metabolism report depends less on the raw file and more on the interpretation model. A pathway-level report is usually more useful than a report that treats every variant as a separate conclusion.
Is DNA metabolism analysis worth it?
is DNA metabolism analysis worth it
DNA metabolism analysis is only worth it if it helps you prioritize what to validate next. A report that just lists variants or broad wellness traits usually is not worth much.
Is this medical advice?
is this medical advice
A pathway-based DNA report is not medical advice. Its job is to organize genetic signals into testable biological hypotheses and suggest what may be worth validating next.