What this pathway does
The pathway coordinates inflammatory signaling, downstream acute-phase response, and the broader immune tone that shapes recovery and symptom intensity.
Why it matters
It matters because inflammation changes how many other pathways behave, including histamine, oxidative stress, and iron handling.
What creates pressure on this pathway
- stronger inflammatory signaling under immune or environmental load
- more spillover into ferritin, histamine, or redox interpretation
Validation markers to consider
- hsCRP
- ferritin context
- CBC and broader inflammatory context
Genes and SNPs connected to this pathway
Inflammation is your immune system's alarm response. It helps fight threats, but too much or too often can make you feel worse.
Study rows support the SNP/gene claim. The pathway connection comes from the curated gene-to-pathway map.
What may run higher
Your immune alarm may turn on too easily or stay on too long.
What may work more slowly
Your immune alarm may be slower or weaker.
What to check next
Check hs-CRP, CBC with differential, ferritin context, fasting glucose, HbA1c, lipid markers, sleep, infection, and injury history.
CRP2 SNPs - 4 claimsShow SNPs
Open gene pagers12053 claims - 9 study rows
biomarker tendency - TT
CRP biomarker tendency
rs1205 TT is associated with reduced CRP biomarker tendency.
CRP rs1205 is scored as a lower circulating C-reactive-protein biomarker tendency for T-containing genotypes, strongest for TT and intermediate for CT.
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biomarker tendency - CT
CRP biomarker tendency
rs1205 CT is associated with reduced CRP biomarker tendency.
CRP rs1205 is scored as a lower circulating C-reactive-protein biomarker tendency for T-containing genotypes, strongest for TT and intermediate for CT.
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biomarker tendency - CC
CRP biomarker tendency
rs1205 CC has no scored directional claim for CRP biomarker tendency.
CRP rs1205 is scored as a lower circulating C-reactive-protein biomarker tendency for T-containing genotypes, strongest for TT and intermediate for CT.
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rs18009471 claims - 2 study rows
biomarker tendency - C
serum C-reactive protein biomarker tendency
rs1800947 C in CRP is associated with lower circulating C-reactive protein tendency.
CRP rs1800947 C is staged as a lower serum CRP biomarker allele.
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NFKB11 SNPs - 3 claimsShow SNPs
Open gene pagers46480683 claims - 6 study rows
expression - GG
NFKB1 gene expression
rs4648068 GG is associated with increased NFKB1 gene expression.
NFKB1 rs4648068 is scored as a higher NFKB1 expression tendency for G-containing genotypes, strongest for GG and intermediate for AG.
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expression - AG
NFKB1 gene expression
rs4648068 AG is associated with increased NFKB1 gene expression.
NFKB1 rs4648068 is scored as a higher NFKB1 expression tendency for G-containing genotypes, strongest for GG and intermediate for AG.
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expression - AA
NFKB1 gene expression
rs4648068 AA has no scored directional claim for NFKB1 gene expression.
NFKB1 rs4648068 is scored as a higher NFKB1 expression tendency for G-containing genotypes, strongest for GG and intermediate for AG.
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NLRP32 SNPs - 2 claimsShow SNPs
Open gene pagers107545581 claims - 2 study rows
biomarker tendency - G
IL-1 beta inflammasome biomarker tendency
rs10754558 G at NLRP3 is associated with higher IL-1 beta inflammatory biomarker tendency in inflammatory disease cohorts.
NLRP3 rs10754558 G is staged as a higher IL-1 beta inflammasome biomarker tendency; generalized higher NLRP3 expression is not asserted.
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rs358294191 claims - 1 study rows
biomarker tendency - A
NLRP3 inflammasome cytokine tendency
rs35829419 A / NLRP3 Gln705Lys is associated with higher NLRP3 inflammasome IL-1 beta and IL-18 production tendency in stimulated-cell context.
NLRP3 rs35829419 A is staged as a low-penetrance gain-of-function inflammasome cytokine tendency allele.
FOXO31 SNPs - 1 claimsShow SNPs
Open gene pagers122120671 claims - 2 study rows
biomarker tendency - G
monocyte inflammatory cytokine response tendency
rs12212067 G is associated with lower stimulated monocyte pro-inflammatory cytokine response tendency.
FOXO3 rs12212067 G is staged as lower monocyte TNF-alpha / IL-1 beta / IL-6 / IL-8 response and higher IL-10 tendency under inflammatory stimulation.
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IL1RN1 SNPs - 1 claimsShow SNPs
Open gene pagers42519611 claims - 1 study rows
biomarker tendency - C
IL-1 receptor antagonist buffering tendency
rs4251961 C is associated with lower IL-1 receptor antagonist production and higher systemic inflammatory-marker tendency.
IL1RN rs4251961 C is staged as reduced IL-1RA buffering, which can increase IL-1 inflammatory tone.
IL6R1 SNPs - 1 claimsShow SNPs
Open gene pagers22281451 claims - 2 study rows
biomarker tendency - C
classical IL-6 receptor signaling tendency
rs2228145 C / Ala358 is associated with lower membrane IL-6R classical signaling tendency and higher soluble IL-6R.
IL6R rs2228145 C is staged for reduced membrane/classical IL-6R signaling, not as a generic lower-inflammation claim.
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KLKB11 SNPs - 1 claimsShow SNPs
Open gene pagers1219649521 claims - 2 study rows
enzyme activity - AA or compound-heterozygous KLKB1 deficiency context
Plasma prekallikrein activity tendency
rs121964952 A / KLKB1 c.367G>A / p.Gly123Arg is associated with lower plasma prekallikrein activity in recessive or compound-heterozygous prekallikrein deficiency contexts.
KLKB1 rs121964952 A is staged as a plasma prekallikrein deficiency allele affecting contact-system protease activation and kinin biology.
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MBL21 SNPs - 1 claimsShow SNPs
Open gene pagers18004501 claims - 2 study rows
biomarker tendency - A
serum mannose-binding lectin tendency
rs1800450 A / MBL2 codon 54 B allele is associated with lower serum mannose-binding lectin tendency.
MBL2 rs1800450 A is staged as a lower circulating MBL protein and lectin-complement support allele.
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P2RX71 SNPs - 1 claimsShow SNPs
Open gene pagers37511431 claims - 2 study rows
enzyme activity - C
P2X7 ATP receptor signaling tendency
rs3751143 C / P2RX7 Ala496 is associated with lower P2X7 ATP-gated receptor signaling tendency.
P2RX7 rs3751143 C is staged as a loss-of-function inflammatory receptor-signaling allele.
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SERPING11 SNPs - 1 claimsShow SNPs
Open gene pagers289408701 claims - 2 study rows
enzyme activity - T / p.Arg466Cys in heterozygous SERPING1 deficiency context
C1 inhibitor contact-system activity tendency
rs28940870 T / SERPING1 c.1396C>T / p.Arg466Cys is associated with lower functional C1 inhibitor control of complement and contact-system proteases in hereditary angioedema contexts.
SERPING1 rs28940870 T is staged as a pathogenic reactive-site allele affecting C1 inhibitor function, complement C4 context, and bradykinin/contact-system inflammatory regulation.
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TLR11 SNPs - 1 claimsShow SNPs
Open gene pagers57436181 claims - 2 study rows
expression - GG
TLR1 surface trafficking tendency
rs5743618 GG / 602S/S is associated with lower TLR1 surface trafficking and lower soluble TLR1/2 agonist response.
TLR1 rs5743618 G is staged as a recessive surface-trafficking and soluble agonist-response variant.
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Where DNA analysis helps
DNA helps decide whether inflammation belongs in the main follow-up layer instead of being treated as a vague background concept.
Example interpretation
Inflammation may deserve separate follow-up when immune-tone genes align with symptom and biomarker context.
Suggested validation: hsCRP plus ferritin context.
What to do next
- validate hsCRP before over-reading immune genetics
- compare inflammatory genes with histamine and oxidative-stress signals as one cluster