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Primary topic: CRP gene DNA analysis

CRP Gene and Metabolism: What It Can Mean in a Pathway Report

CRP becomes more useful when inflammation / immune signaling looks like a meaningful follow-up area instead of just background context.

What is the CRP gene?

CRP contributes to how inflammatory tone shows up in biomarker follow-up. That makes it more useful as part of a pathway view than as an isolated SNP call.

How CRP affects metabolism

If CRP-related support is less favorable, the pathway can look more pressured under load and the linked biomarkers become more useful to validate directly.

What happens when CRP is altered

An altered CRP pattern does not diagnose anything on its own, but it does change which follow-up markers deserve attention first.

Curated SNP evidence for CRP

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Inflammation / immune signaling Iron handling

Evidence-backed report connection

CRP currently has 3 curated SNPs, 10 claim-level scores, and 3 claims eligible for pathway scoring.

Open the sample report
rs1205CRP supporting signal3 claims · 9 study rows

biomarker tendency · TT

CRP biomarker tendency

Strong

rs1205 TT is associated with reduced CRP biomarker tendency.

CRP rs1205 is scored as a lower circulating C-reactive-protein biomarker tendency for T-containing genotypes, strongest for TT and intermediate for CT.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP maps rs1205 to CRP and lists C and T as observed letters. CRP encodes C-reactive protein, so this record is framed as a CRP biomarker tendency rather than enzyme or transport activity.PMC11045144biomarker association · close proxyThis open-access Strong Heart Study report describes rs1205 as a C/T variant in the 3' untranslated region of CRP and summarizes prior evidence that each additional T allele is consistently associated with lower serum CRP. This supports lower CRP biomarker tendency for T-containing genotypes.PubMed 21300955gwas · close proxyA large meta-analysis of genome-wide association studies in more than 80,000 participants identified CRP-region variants among the loci associated with circulating C-reactive protein levels. This supports treating rs1205 as part of a biomarker tendency, not as a standalone disease result.

biomarker tendency · CT

CRP biomarker tendency

Moderate

rs1205 CT is associated with reduced CRP biomarker tendency.

CRP rs1205 is scored as a lower circulating C-reactive-protein biomarker tendency for T-containing genotypes, strongest for TT and intermediate for CT.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP maps rs1205 to CRP and lists C and T as observed letters. CRP encodes C-reactive protein, so this record is framed as a CRP biomarker tendency rather than enzyme or transport activity.PMC11045144biomarker association · close proxyThis open-access Strong Heart Study report describes rs1205 as a C/T variant in the 3' untranslated region of CRP and summarizes prior evidence that each additional T allele is consistently associated with lower serum CRP. This supports lower CRP biomarker tendency for T-containing genotypes.PubMed 21300955gwas · close proxyA large meta-analysis of genome-wide association studies in more than 80,000 participants identified CRP-region variants among the loci associated with circulating C-reactive protein levels. This supports treating rs1205 as part of a biomarker tendency, not as a standalone disease result.

biomarker tendency · CC

CRP biomarker tendency

Not used for pathway scoring

rs1205 CC has no scored directional claim for CRP biomarker tendency.

CRP rs1205 is scored as a lower circulating C-reactive-protein biomarker tendency for T-containing genotypes, strongest for TT and intermediate for CT.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP maps rs1205 to CRP and lists C and T as observed letters. CRP encodes C-reactive protein, so this record is framed as a CRP biomarker tendency rather than enzyme or transport activity.PMC11045144biomarker association · close proxyThis open-access Strong Heart Study report describes rs1205 as a C/T variant in the 3' untranslated region of CRP and summarizes prior evidence that each additional T allele is consistently associated with lower serum CRP. This supports lower CRP biomarker tendency for T-containing genotypes.PubMed 21300955gwas · close proxyA large meta-analysis of genome-wide association studies in more than 80,000 participants identified CRP-region variants among the loci associated with circulating C-reactive protein levels. This supports treating rs1205 as part of a biomarker tendency, not as a standalone disease result.
rs1800947CRP +1059G>C1 claims · 2 study rows

biomarker tendency · C

serum C-reactive protein biomarker tendency

Moderate

rs1800947 C in CRP is associated with lower circulating C-reactive protein tendency.

CRP rs1800947 C is staged as a lower serum CRP biomarker allele.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
PMCID PMC9013148biomarker association · directThe checked LBA cohort source reports rs1800947 was associated with CRP levels, with the minor C allele contributing GC/CC genotypes associated with lower median CRP levels; in men rs1800947 was the only SNP significantly associated with CRP.PMCID PMC4312833biomarker association · directThe checked elderly cohort source includes rs1800947 among CRP variants evaluated for circulating high-sensitivity CRP and supports sex-specific CRP-genotype effects, providing non-review biomarker context for the exact SNP.
rs3091244CRP supporting signal6 claims · 18 study rows

expression · AA

CRP gene expression

Not used for pathway scoring

rs3091244 AA is associated with increased CRP gene expression.

CRP rs3091244 is scored as a modest tendency toward higher CRP gene expression for A-containing genotypes, strongest for AA. The T-only signal is kept neutral because the evidence is less consistent.

Likely effectHigher gene expression signal
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs3091244 as a CRP-region variant with observed genomic letters G, A, and T. This supports a tri-allelic genotype record for CRP expression rather than an enzyme or transporter activity record.PMC2630773biomarker association · loose proxyAn African American fine-mapping study measured serum CRP and found strong support for triallelic rs3091244 as a key CRP-regulating signal. The clearest association was additive for one allele, while evidence for the other non-baseline allele was weak, so this file scores the clearer allele and leaves the weaker one neutral.PMC1226195expression eqtl · directA CRP promoter study reported that promoter-region variants including rs3091244 were associated with plasma CRP levels and had functional promoter effects in vitro. The authors also described one rs3091244 allele as part of the lower-CRP pattern, supporting an expression-level interpretation rather than disease prediction.

expression · AG

CRP gene expression

Not used for pathway scoring

rs3091244 AG is associated with increased CRP gene expression.

CRP rs3091244 is scored as a modest tendency toward higher CRP gene expression for A-containing genotypes, strongest for AA. The T-only signal is kept neutral because the evidence is less consistent.

Likely effectHigher gene expression signal
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs3091244 as a CRP-region variant with observed genomic letters G, A, and T. This supports a tri-allelic genotype record for CRP expression rather than an enzyme or transporter activity record.PMC2630773biomarker association · loose proxyAn African American fine-mapping study measured serum CRP and found strong support for triallelic rs3091244 as a key CRP-regulating signal. The clearest association was additive for one allele, while evidence for the other non-baseline allele was weak, so this file scores the clearer allele and leaves the weaker one neutral.PMC1226195expression eqtl · directA CRP promoter study reported that promoter-region variants including rs3091244 were associated with plasma CRP levels and had functional promoter effects in vitro. The authors also described one rs3091244 allele as part of the lower-CRP pattern, supporting an expression-level interpretation rather than disease prediction.

expression · AT

CRP gene expression

Not used for pathway scoring

rs3091244 AT is associated with increased CRP gene expression.

CRP rs3091244 is scored as a modest tendency toward higher CRP gene expression for A-containing genotypes, strongest for AA. The T-only signal is kept neutral because the evidence is less consistent.

Likely effectHigher gene expression signal
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs3091244 as a CRP-region variant with observed genomic letters G, A, and T. This supports a tri-allelic genotype record for CRP expression rather than an enzyme or transporter activity record.PMC2630773biomarker association · loose proxyAn African American fine-mapping study measured serum CRP and found strong support for triallelic rs3091244 as a key CRP-regulating signal. The clearest association was additive for one allele, while evidence for the other non-baseline allele was weak, so this file scores the clearer allele and leaves the weaker one neutral.PMC1226195expression eqtl · directA CRP promoter study reported that promoter-region variants including rs3091244 were associated with plasma CRP levels and had functional promoter effects in vitro. The authors also described one rs3091244 allele as part of the lower-CRP pattern, supporting an expression-level interpretation rather than disease prediction.

expression · GG

CRP gene expression

Not used for pathway scoring

rs3091244 GG has no scored directional claim for CRP gene expression.

CRP rs3091244 is scored as a modest tendency toward higher CRP gene expression for A-containing genotypes, strongest for AA. The T-only signal is kept neutral because the evidence is less consistent.

Likely effectNo clear expression signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs3091244 as a CRP-region variant with observed genomic letters G, A, and T. This supports a tri-allelic genotype record for CRP expression rather than an enzyme or transporter activity record.PMC2630773biomarker association · loose proxyAn African American fine-mapping study measured serum CRP and found strong support for triallelic rs3091244 as a key CRP-regulating signal. The clearest association was additive for one allele, while evidence for the other non-baseline allele was weak, so this file scores the clearer allele and leaves the weaker one neutral.PMC1226195expression eqtl · directA CRP promoter study reported that promoter-region variants including rs3091244 were associated with plasma CRP levels and had functional promoter effects in vitro. The authors also described one rs3091244 allele as part of the lower-CRP pattern, supporting an expression-level interpretation rather than disease prediction.

expression · GT

CRP gene expression

Not used for pathway scoring

rs3091244 GT has no scored directional claim for CRP gene expression.

CRP rs3091244 is scored as a modest tendency toward higher CRP gene expression for A-containing genotypes, strongest for AA. The T-only signal is kept neutral because the evidence is less consistent.

Likely effectNo clear expression signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs3091244 as a CRP-region variant with observed genomic letters G, A, and T. This supports a tri-allelic genotype record for CRP expression rather than an enzyme or transporter activity record.PMC2630773biomarker association · loose proxyAn African American fine-mapping study measured serum CRP and found strong support for triallelic rs3091244 as a key CRP-regulating signal. The clearest association was additive for one allele, while evidence for the other non-baseline allele was weak, so this file scores the clearer allele and leaves the weaker one neutral.PMC1226195expression eqtl · directA CRP promoter study reported that promoter-region variants including rs3091244 were associated with plasma CRP levels and had functional promoter effects in vitro. The authors also described one rs3091244 allele as part of the lower-CRP pattern, supporting an expression-level interpretation rather than disease prediction.

expression · TT

CRP gene expression

Not used for pathway scoring

rs3091244 TT has no scored directional claim for CRP gene expression.

CRP rs3091244 is scored as a modest tendency toward higher CRP gene expression for A-containing genotypes, strongest for AA. The T-only signal is kept neutral because the evidence is less consistent.

Likely effectNo clear expression signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs3091244 as a CRP-region variant with observed genomic letters G, A, and T. This supports a tri-allelic genotype record for CRP expression rather than an enzyme or transporter activity record.PMC2630773biomarker association · loose proxyAn African American fine-mapping study measured serum CRP and found strong support for triallelic rs3091244 as a key CRP-regulating signal. The clearest association was additive for one allele, while evidence for the other non-baseline allele was weak, so this file scores the clearer allele and leaves the weaker one neutral.PMC1226195expression eqtl · directA CRP promoter study reported that promoter-region variants including rs3091244 were associated with plasma CRP levels and had functional promoter effects in vitro. The authors also described one rs3091244 allele as part of the lower-CRP pattern, supporting an expression-level interpretation rather than disease prediction.

Common symptoms people report

  • inflammation / immune signaling can overlap with more persistent symptom patterns
  • marker-driven follow-up may matter more than generic advice
  • mixed responses can make the pathway easier to miss without structured review

Biomarkers to validate

Ferritin context

Primary follow-up marker for CRP inside inflammation / immune signaling.

Related pathway markers

Useful when the pathway needs to be validated as a system rather than as one variant.

Where DNA analysis helps

DNA helps decide whether CRP should move inflammation / immune signaling higher on the follow-up list before broad interventions are assumed.

Example interpretation

CRP can strengthen the case for inflammation / immune signaling follow-up when the rest of the pathway points in a similar direction.

Suggested validation: Ferritin context.

What to do next

  • Use Ferritin context and pathway context before assuming the gene matters in practice.
  • Read CRP alongside the related genes in the same pathway instead of as a standalone result.

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