What is the ACADM gene?
Medium-chain acyl-CoA dehydrogenase for mitochondrial medium-chain fatty-acid beta-oxidation.
How ACADM affects metabolism
When ACADM-related function is shifted, the practical effect is interpreted through fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. This does not mean the pathway is active or impaired right now; it means the gene can help prioritize what to check next.
What happens when ACADM is altered
Altered ACADM signal should be treated as a DNA-based tendency, not a diagnosis. 1 claim currently passes the report-use gate. The useful question is whether symptoms, labs, and lifestyle context line up with the pathway signal.
Curated SNP evidence for ACADM
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
ACADM currently has 1 curated SNPs, 1 claim-level scores, and 1 claims eligible for pathway scoring.
Open the sample reportrs77931234ACADM c.985A>G / Lys329Glu1 claims · 2 study rows
enzyme activity · GG
MCAD activity tendency
rs77931234 GG / ACADM c.985A>G is associated with markedly lower MCAD activity tendency.
ACADM rs77931234 G is staged as a recessive clinical metabolic enzyme variant.
Show study evidence
Common symptoms people report
- low energy under fasting, illness, or exercise
- slow recovery after exertion
- fatigue that feels out of proportion to workload
Biomarkers to validate
CBC, ferritin, and thyroid context
Rules out common non-DNA explanations for low energy.
Glucose and HbA1c
Checks whether fuel handling is adding pressure.
Organic acids or acylcarnitines when available
Adds more specific mitochondrial and fatty-acid oxidation context.
Where DNA analysis helps
DNA helps decide whether ACADM deserves attention inside the broader Mitochondrial energy pathway. It is most useful when combined with biomarkers instead of used as a standalone answer.
Example interpretation
ACADM may add context to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism, especially when its SNP evidence lines up with other genes in the same pathway.
Suggested validation: CBC, ferritin, and thyroid context.
What to do next
- Review the Mitochondrial energy pathway result before interpreting ACADM on its own.
- Use relevant biomarkers to confirm whether this DNA tendency is visible in current biology.
- Treat supplement or nutrition decisions as follow-up steps only after the pattern fits symptoms or labs.
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