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Primary topic: SULT1A1 gene DNA analysis

SULT1A1 Gene and Metabolism: What It Can Mean in a Pathway Report

SULT1A1 becomes more useful when estrogen metabolism looks like a meaningful follow-up area instead of just background context.

What is the SULT1A1 gene?

SULT1A1 contributes to sulfation support for hormone and phenol clearance. That makes it more useful as part of a pathway view than as an isolated SNP call.

How SULT1A1 affects metabolism

If SULT1A1-related support is less favorable, the pathway can look more pressured under load and the linked biomarkers become more useful to validate directly.

What happens when SULT1A1 is altered

An altered SULT1A1 pattern does not diagnose anything on its own, but it does change which follow-up markers deserve attention first.

Curated SNP evidence for SULT1A1

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Estrogen metabolism

Evidence-backed report connection

SULT1A1 currently has 2 curated SNPs, 6 claim-level scores, and 0 claims eligible for pathway scoring.

Open the sample report
rs1801030SULT1A1 supporting signal3 claims · 9 study rows

unknown · CC

SULT1A1 unscored target

Not used for pathway scoring

rs1801030 CC has no scored directional claim for SULT1A1 unscored target.

SULT1A1 rs1801030 is kept neutral because the available evidence does not support a simple, general end-user enzyme-activity direction for these genotype labels.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1801030 in SULT1A1 and annotates coding consequences for SULT1A1 transcripts. The public record includes C and T as common population allele labels, supporting the SULT1A1 gene assignment and the C/T genotype labels used here.PMC4436276other · loose proxyAn open full-text genetic association study identifies rs1801030 as a SULT1A1 non-synonymous variant and notes earlier reports that SULT1A1 exon 7 variants can affect activity and thermostability. The study context is disease association rather than a simple measured enzyme-activity result for end users.Evidence 3review · close proxyA pharmacogenomics review lists SULT1A1 rs1801030 among phase II metabolism variants with reported drug-response relevance. Because SULT1A1 findings are substrate-specific and not summarized as a single reliable consumer-facing direction for this marker, a neutral interpretation is the safer end-user summary.

unknown · CT

SULT1A1 unscored target

Not used for pathway scoring

rs1801030 CT has no scored directional claim for SULT1A1 unscored target.

SULT1A1 rs1801030 is kept neutral because the available evidence does not support a simple, general end-user enzyme-activity direction for these genotype labels.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1801030 in SULT1A1 and annotates coding consequences for SULT1A1 transcripts. The public record includes C and T as common population allele labels, supporting the SULT1A1 gene assignment and the C/T genotype labels used here.PMC4436276other · loose proxyAn open full-text genetic association study identifies rs1801030 as a SULT1A1 non-synonymous variant and notes earlier reports that SULT1A1 exon 7 variants can affect activity and thermostability. The study context is disease association rather than a simple measured enzyme-activity result for end users.Evidence 3review · close proxyA pharmacogenomics review lists SULT1A1 rs1801030 among phase II metabolism variants with reported drug-response relevance. Because SULT1A1 findings are substrate-specific and not summarized as a single reliable consumer-facing direction for this marker, a neutral interpretation is the safer end-user summary.

unknown · TT

SULT1A1 unscored target

Not used for pathway scoring

rs1801030 TT has no scored directional claim for SULT1A1 unscored target.

SULT1A1 rs1801030 is kept neutral because the available evidence does not support a simple, general end-user enzyme-activity direction for these genotype labels.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1801030 in SULT1A1 and annotates coding consequences for SULT1A1 transcripts. The public record includes C and T as common population allele labels, supporting the SULT1A1 gene assignment and the C/T genotype labels used here.PMC4436276other · loose proxyAn open full-text genetic association study identifies rs1801030 as a SULT1A1 non-synonymous variant and notes earlier reports that SULT1A1 exon 7 variants can affect activity and thermostability. The study context is disease association rather than a simple measured enzyme-activity result for end users.Evidence 3review · close proxyA pharmacogenomics review lists SULT1A1 rs1801030 among phase II metabolism variants with reported drug-response relevance. Because SULT1A1 findings are substrate-specific and not summarized as a single reliable consumer-facing direction for this marker, a neutral interpretation is the safer end-user summary.
rs9282861Arg213His3 claims · 6 study rows

enzyme activity · AA

SULT1A1 enzyme activity

Not used for pathway scoring

rs9282861 AA is associated with reduced SULT1A1 enzyme activity.

SULT1A1 rs9282861 is scored as a lower sulfotransferase enzyme-activity tendency when the A allele is present, with a stronger score for AA than AG.

Likely effectLower enzyme activity signal
Signal sizeSmall signal
Evidence supportLimited support
Report useEvidence only, not scored
Show study evidence
Evidence 1review · directA pharmacogenetics review describes human SULT enzymes as sulfate-conjugating enzymes and lists SULT1A1*2 as rs9282861 G>A. It also notes that SULT1A1 copy number and promoter variants can affect total SULT1A1 function, so this SNP alone should be interpreted cautiously.PubMed 10review · directA PLOS One meta-analysis describes rs9282861 as the SULT1A1 Arg213His change caused by a G>A transition at codon 213 and states that prior studies showed decreased SULT1A1 enzymatic activity and sulfonation efficiency for this polymorphism. The same paper reports heterogeneous disease-association findings, so this file only scores enzyme-activity tendency.

enzyme activity · AG

SULT1A1 enzyme activity

Not used for pathway scoring

rs9282861 AG is associated with reduced SULT1A1 enzyme activity.

SULT1A1 rs9282861 is scored as a lower sulfotransferase enzyme-activity tendency when the A allele is present, with a stronger score for AA than AG.

Likely effectLower enzyme activity signal
Signal sizeSmall signal
Evidence supportLimited support
Report useEvidence only, not scored
Show study evidence
Evidence 1review · directA pharmacogenetics review describes human SULT enzymes as sulfate-conjugating enzymes and lists SULT1A1*2 as rs9282861 G>A. It also notes that SULT1A1 copy number and promoter variants can affect total SULT1A1 function, so this SNP alone should be interpreted cautiously.PubMed 10review · directA PLOS One meta-analysis describes rs9282861 as the SULT1A1 Arg213His change caused by a G>A transition at codon 213 and states that prior studies showed decreased SULT1A1 enzymatic activity and sulfonation efficiency for this polymorphism. The same paper reports heterogeneous disease-association findings, so this file only scores enzyme-activity tendency.

enzyme activity · GG

SULT1A1 enzyme activity

Not used for pathway scoring

rs9282861 GG has no scored directional claim for SULT1A1 enzyme activity.

SULT1A1 rs9282861 is scored as a lower sulfotransferase enzyme-activity tendency when the A allele is present, with a stronger score for AA than AG.

Likely effectNo clear enzyme signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
Evidence 1review · directA pharmacogenetics review describes human SULT enzymes as sulfate-conjugating enzymes and lists SULT1A1*2 as rs9282861 G>A. It also notes that SULT1A1 copy number and promoter variants can affect total SULT1A1 function, so this SNP alone should be interpreted cautiously.PubMed 10review · directA PLOS One meta-analysis describes rs9282861 as the SULT1A1 Arg213His change caused by a G>A transition at codon 213 and states that prior studies showed decreased SULT1A1 enzymatic activity and sulfonation efficiency for this polymorphism. The same paper reports heterogeneous disease-association findings, so this file only scores enzyme-activity tendency.

Common symptoms people report

  • estrogen metabolism can overlap with more persistent symptom patterns
  • marker-driven follow-up may matter more than generic advice
  • mixed responses can make the pathway easier to miss without structured review

Biomarkers to validate

SHBG

Primary follow-up marker for SULT1A1 inside estrogen metabolism.

Related pathway markers

Useful when the pathway needs to be validated as a system rather than as one variant.

Where DNA analysis helps

DNA helps decide whether SULT1A1 should move estrogen metabolism higher on the follow-up list before broad interventions are assumed.

Example interpretation

SULT1A1 can strengthen the case for estrogen metabolism follow-up when the rest of the pathway points in a similar direction.

Suggested validation: SHBG.

What to do next

  • Use SHBG and pathway context before assuming the gene matters in practice.
  • Read SULT1A1 alongside the related genes in the same pathway instead of as a standalone result.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

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