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Primary topic: LPL triglyceride clearance gene

LPL Gene and Metabolism: What It Means for Your Body

LPL becomes important when triglyceride clearance and fat handling look like the real lipid bottleneck.

What is the LPL gene?

LPL helps break down triglyceride-rich lipoproteins so fatty acids can be cleared and used. That makes it one of the more direct clearance-side genes in lipid handling.

How LPL affects metabolism

If LPL-related clearance is less efficient, triglycerides can stay higher and lipid handling can look more sluggish under metabolic load.

What happens when LPL is altered

Altered LPL function does not diagnose dyslipidemia, but it increases the value of validating triglycerides and broader lipid context directly.

Curated SNP evidence for LPL

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Lipids

Evidence-backed report connection

LPL currently has 3 curated SNPs, 7 claim-level scores, and 1 claims eligible for pathway scoring.

Open the sample report
rs13702LPL rs13702 miR-410 site1 claims · 2 study rows

enzyme activity · C

LPL triglyceride clearance tendency

Strong

rs13702 C in the LPL 3-prime UTR is associated with higher LPL activity/expression tendency and lower triglyceride tendency.

LPL rs13702 C is staged as a gain-of-function triglyceride-clearance allele.

Likely effectHigher enzyme activity signal
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
AJHG rs13702 miR-410 functional studyfunctional assay · directThe checked article identifies rs13702 as a gain-of-function LPL variant that modulates lipid traits through disruption of a miR-410 seed site.PMID 24990426biomarker association · directThe checked PREDIMED report states that rs13702T>C was strongly associated with lower triglycerides in C-allele carriers and that the association was modified by dietary unsaturated fat intervention.
rs268LPL supporting signal3 claims · 15 study rows

enzyme activity · AG

LPL enzyme activity

Not used for pathway scoring

rs268 AG is associated with reduced LPL enzyme activity.

LPL rs268 G-containing genotypes are scored as a lower LPL enzyme-activity tendency, with modest certainty because clinical and association evidence is mixed.

Likely effectLower enzyme activity signal
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs268 in LPL, the lipoprotein lipase gene, and annotate the G-containing allele as a missense variant. The common literature coding for this SNP uses A and G genotype letters.PubMed 11427211biomarker association · loose proxyA study of LPL D9N, N291S, and S447X reported generally more adverse HDL-C and triglyceride patterns in carriers of the 291S allele, with significantly lower HDL-C in a community group. This supports a lower LPL activity-related tendency for rs268 G carriers.PubMed 23761384functional assay · directA familial LPL deficiency case report involving the common N291S mutation found reduced post-heparin total lipase activity in biochemical testing. This supports cautious functional interpretation while recognizing that severe deficiency usually involves broader genetic context.PubMed 18922999review · directA HuGE review and meta-analysis of seven LPL polymorphisms reported that N291S rs268 carriers had modestly adverse lipid profiles, while the combined coronary heart disease estimate was close to null. This supports a lower LPL enzyme-activity tendency with moderate-to-low certainty.ClinVar recordclinical curation · directClinVar lists mixed clinical assertions for rs268 in LPL. The clinical curation does not provide direct per-genotype LPL activity evidence, so it is retained as context only.

enzyme activity · GG

LPL enzyme activity

Not used for pathway scoring

rs268 GG is associated with reduced LPL enzyme activity.

LPL rs268 G-containing genotypes are scored as a lower LPL enzyme-activity tendency, with modest certainty because clinical and association evidence is mixed.

Likely effectLower enzyme activity signal
Signal sizeSmall signal
Evidence supportLimited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs268 in LPL, the lipoprotein lipase gene, and annotate the G-containing allele as a missense variant. The common literature coding for this SNP uses A and G genotype letters.PubMed 11427211biomarker association · loose proxyA study of LPL D9N, N291S, and S447X reported generally more adverse HDL-C and triglyceride patterns in carriers of the 291S allele, with significantly lower HDL-C in a community group. This supports a lower LPL activity-related tendency for rs268 G carriers.PubMed 23761384functional assay · directA familial LPL deficiency case report involving the common N291S mutation found reduced post-heparin total lipase activity in biochemical testing. This supports cautious functional interpretation while recognizing that severe deficiency usually involves broader genetic context.PubMed 18922999review · directA HuGE review and meta-analysis of seven LPL polymorphisms reported that N291S rs268 carriers had modestly adverse lipid profiles, while the combined coronary heart disease estimate was close to null. This supports a lower LPL enzyme-activity tendency with moderate-to-low certainty.ClinVar recordclinical curation · directClinVar lists mixed clinical assertions for rs268 in LPL. The clinical curation does not provide direct per-genotype LPL activity evidence, so it is retained as context only.

enzyme activity · AA

LPL enzyme activity

Not used for pathway scoring

rs268 AA has no scored directional claim for LPL enzyme activity.

LPL rs268 G-containing genotypes are scored as a lower LPL enzyme-activity tendency, with modest certainty because clinical and association evidence is mixed.

Likely effectNo clear enzyme signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs268 in LPL, the lipoprotein lipase gene, and annotate the G-containing allele as a missense variant. The common literature coding for this SNP uses A and G genotype letters.PubMed 11427211biomarker association · loose proxyA study of LPL D9N, N291S, and S447X reported generally more adverse HDL-C and triglyceride patterns in carriers of the 291S allele, with significantly lower HDL-C in a community group. This supports a lower LPL activity-related tendency for rs268 G carriers.PubMed 23761384functional assay · directA familial LPL deficiency case report involving the common N291S mutation found reduced post-heparin total lipase activity in biochemical testing. This supports cautious functional interpretation while recognizing that severe deficiency usually involves broader genetic context.PubMed 18922999review · directA HuGE review and meta-analysis of seven LPL polymorphisms reported that N291S rs268 carriers had modestly adverse lipid profiles, while the combined coronary heart disease estimate was close to null. This supports a lower LPL enzyme-activity tendency with moderate-to-low certainty.ClinVar recordclinical curation · directClinVar lists rs268 in LPL with mixed clinical assertions across conditions. This supports conservative interpretation focused on enzyme-activity tendency rather than using this SNP alone for disease prediction.
rs328S447X3 claims · 12 study rows

enzyme activity · CG

LPL enzyme activity

Not used for pathway scoring

rs328 CG is associated with increased LPL enzyme activity.

LPL rs328 G-containing genotypes are scored as a higher LPL enzyme-activity tendency, with GG scored stronger than CG.

Likely effectHigher enzyme activity signal
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs328 in LPL, the lipoprotein lipase gene, and annotate the G-containing allele with a stop-gained consequence. The common literature coding for this SNP uses C and G genotype letters.PubMed 22244040functional assay · loose proxyRanganathan et al. describe LPL S447X as a common gain-of-function variant caused by a C-to-G base change and provide a mechanism involving reduced susceptibility to translational inhibition.PMC3183417biomarker association · loose proxyJensen et al. describe rs328 as the LPL S447X variant and note prior evidence that the variant protein has higher lipolytic function. Their cohort analysis treated S447X as a lipid-related LPL variant rather than a deterministic disease marker.PubMed 18922999review · directA HuGE review and meta-analysis of LPL polymorphisms reported modestly advantageous lipid profiles and lower combined coronary heart disease odds for carriers of 447X. This supports an increased LPL enzyme-activity tendency with conservative end-user wording.

enzyme activity · GG

LPL enzyme activity

Not used for pathway scoring

rs328 GG is associated with increased LPL enzyme activity.

LPL rs328 G-containing genotypes are scored as a higher LPL enzyme-activity tendency, with GG scored stronger than CG.

Likely effectHigher enzyme activity signal
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs328 in LPL, the lipoprotein lipase gene, and annotate the G-containing allele with a stop-gained consequence. The common literature coding for this SNP uses C and G genotype letters.PubMed 22244040functional assay · loose proxyRanganathan et al. describe LPL S447X as a common gain-of-function variant caused by a C-to-G base change and provide a mechanism involving reduced susceptibility to translational inhibition.PMC3183417biomarker association · loose proxyJensen et al. describe rs328 as the LPL S447X variant and note prior evidence that the variant protein has higher lipolytic function. Their cohort analysis treated S447X as a lipid-related LPL variant rather than a deterministic disease marker.PubMed 18922999review · directA HuGE review and meta-analysis of LPL polymorphisms reported modestly advantageous lipid profiles and lower combined coronary heart disease odds for carriers of 447X. This supports an increased LPL enzyme-activity tendency with conservative end-user wording.

enzyme activity · CC

LPL enzyme activity

Not used for pathway scoring

rs328 CC has no scored directional claim for LPL enzyme activity.

LPL rs328 G-containing genotypes are scored as a higher LPL enzyme-activity tendency, with GG scored stronger than CG.

Likely effectNo clear enzyme signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs328 in LPL, the lipoprotein lipase gene, and annotate the G-containing allele with a stop-gained consequence. The common literature coding for this SNP uses C and G genotype letters.PubMed 22244040functional assay · loose proxyRanganathan et al. describe LPL S447X as a common gain-of-function variant caused by a C-to-G base change and provide a mechanism involving reduced susceptibility to translational inhibition.PMC3183417biomarker association · loose proxyJensen et al. describe rs328 as the LPL S447X variant and note prior evidence that the variant protein has higher lipolytic function. Their cohort analysis treated S447X as a lipid-related LPL variant rather than a deterministic disease marker.PubMed 18922999review · directA HuGE review and meta-analysis of LPL polymorphisms reported modestly advantageous lipid profiles and lower combined coronary heart disease odds for carriers of 447X. This supports an increased LPL enzyme-activity tendency with conservative end-user wording.

Common symptoms people report

  • higher triglyceride concern
  • weight or energy issues with lipid overlap
  • unclear response to dietary fat

Biomarkers to validate

Triglycerides

Direct clearance-related follow-up.

ApoB

Particle context when triglycerides are elevated.

Fasting insulin

Useful when lipid and glucose pressure overlap.

Where DNA analysis helps

DNA helps decide whether triglyceride clearance deserves more attention inside a lipid or glucose review.

Example Insight

Your triglyceride-clearance pathway may deserve attention when lipid pressure looks more dynamic than total cholesterol suggests.

Suggested validation: triglycerides plus ApoB.

What to do next

  • Check triglycerides before assuming the pathway is active.
  • Review LPL with APOA5 and PPARA for a fuller clearance picture.
  • Use marker context before changing strategy.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

Get My DNA Report

Related pages

APOA5

APOA5 triglyceride gene

PPARA

PPARA fat metabolism gene

Triglycerides

triglycerides and metabolic health

Fasting insulin

fasting insulin and metabolism

Glucose regulation pathway

glucose regulation pathway

Lipid transport pathway

lipid transport pathway

Genetic test for weight loss Europe

genetic test for weight loss Europe

Related symptom angle

Why do I gain weight easily genetics

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