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Primary topic: GCKR glucose liver gene

GCKR Gene and Metabolism: What It Means for Your Body

GCKR becomes relevant when glucose handling and liver-driven triglyceride patterns overlap.

What is the GCKR gene?

GCKR regulates glucokinase activity in the liver. That links fasting glucose, post-meal handling, and triglyceride production more closely than many people expect.

How GCKR affects metabolism

If GCKR-related regulation is less favorable, glucose and triglyceride patterns can drift together. That makes it useful when meal response and lipid markers do not separate cleanly.

What happens when GCKR is altered

Altered GCKR signaling does not diagnose insulin resistance, but it increases the value of checking both glucose and triglyceride markers together.

Curated SNP evidence for GCKR

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Glucose

Evidence-backed report connection

GCKR currently has 2 curated SNPs, 6 claim-level scores, and 4 claims eligible for pathway scoring.

Open the sample report
rs1260326P446L3 claims · 12 study rows

biomarker tendency · TT

GCKR biomarker tendency

Strong

rs1260326 TT is associated with increased GCKR biomarker tendency.

GCKR rs1260326 T-containing genotypes are scored as a stronger GCKR-linked biomarker tendency, mainly higher triglycerides with lower fasting glucose in population studies.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs1260326 at GCKR, the glucokinase regulator gene. The commonly reported genotype letters for this coding variant are CC, CT, and TT.PMC2570409biomarker association · loose proxyOrho-Melander et al. reported that rs1260326, also described as Pro446Leu, was the strongest GCKR-region association signal and linked the T allele to higher triglycerides and lower fasting glucose across multiple cohorts.PMC2918876biomarker association · close proxyPollin et al. studied a high-fat challenge and reported that the rs1260326 T allele was associated with higher fasting triglycerides and a stronger postprandial triglyceride response. This supports allele-dose scoring for a triglyceride-related biomarker tendency.PMC3720952biomarker association · close proxyThe HALCyon Programme confirmed associations between rs1260326 and triglycerides and glucose in middle-aged to older adults, while also noting environmental modification. This supports a biomarker-tendency interpretation rather than a fixed health outcome.

biomarker tendency · CT

GCKR biomarker tendency

Strong

rs1260326 CT is associated with increased GCKR biomarker tendency.

GCKR rs1260326 T-containing genotypes are scored as a stronger GCKR-linked biomarker tendency, mainly higher triglycerides with lower fasting glucose in population studies.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs1260326 at GCKR, the glucokinase regulator gene. The commonly reported genotype letters for this coding variant are CC, CT, and TT.PMC2570409biomarker association · loose proxyOrho-Melander et al. reported that rs1260326, also described as Pro446Leu, was the strongest GCKR-region association signal and linked the T allele to higher triglycerides and lower fasting glucose across multiple cohorts.PMC2918876biomarker association · close proxyPollin et al. studied a high-fat challenge and reported that the rs1260326 T allele was associated with higher fasting triglycerides and a stronger postprandial triglyceride response. This supports allele-dose scoring for a triglyceride-related biomarker tendency.PMC3720952biomarker association · close proxyThe HALCyon Programme confirmed associations between rs1260326 and triglycerides and glucose in middle-aged to older adults, while also noting environmental modification. This supports a biomarker-tendency interpretation rather than a fixed health outcome.

biomarker tendency · CC

GCKR biomarker tendency

Not used for pathway scoring

rs1260326 CC has no scored directional claim for GCKR biomarker tendency.

GCKR rs1260326 T-containing genotypes are scored as a stronger GCKR-linked biomarker tendency, mainly higher triglycerides with lower fasting glucose in population studies.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs1260326 at GCKR, the glucokinase regulator gene. The commonly reported genotype letters for this coding variant are CC, CT, and TT.PMC2570409biomarker association · loose proxyOrho-Melander et al. reported that rs1260326, also described as Pro446Leu, was the strongest GCKR-region association signal and linked the T allele to higher triglycerides and lower fasting glucose across multiple cohorts.PMC2918876biomarker association · close proxyPollin et al. studied a high-fat challenge and reported that the rs1260326 T allele was associated with higher fasting triglycerides and a stronger postprandial triglyceride response. This supports allele-dose scoring for a triglyceride-related biomarker tendency.PMC3720952biomarker association · close proxyThe HALCyon Programme confirmed associations between rs1260326 and triglycerides and glucose in middle-aged to older adults, while also noting environmental modification. This supports a biomarker-tendency interpretation rather than a fixed health outcome.
rs780094GCKR supporting signal3 claims · 12 study rows

biomarker tendency · TT

GCKR biomarker tendency

Strong

rs780094 TT is associated with increased GCKR biomarker tendency.

GCKR rs780094 T-containing genotypes are scored as a stronger GCKR-linked biomarker tendency, mainly higher triglycerides with lower fasting glucose in population studies.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs780094 at GCKR, the glucokinase regulator gene. The commonly reported genotype letters for end-user literature are CC, CT, and TT.PMC2570409biomarker association · close proxyOrho-Melander et al. reported that rs780094 in the GCKR region was associated with opposite effects on fasting triglycerides and glucose, with the T allele linked to higher triglycerides and lower fasting glucose.PMC2908550biomarker association · loose proxyThe ARIC Study replicated rs780094 T-allele associations with lower fasting glucose, insulin, insulin resistance, and prevalent diabetes, while also reporting higher triglycerides and C-reactive protein in white participants.PMC3720952biomarker association · loose proxyThe HALCyon Programme reviewed rs780094 as one of the GCKR variants tied to metabolic traits and confirmed the closely related functional GCKR signal for triglyceride and glucose measures. This supports conservative biomarker-tendency scoring.

biomarker tendency · CT

GCKR biomarker tendency

Moderate

rs780094 CT is associated with increased GCKR biomarker tendency.

GCKR rs780094 T-containing genotypes are scored as a stronger GCKR-linked biomarker tendency, mainly higher triglycerides with lower fasting glucose in population studies.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs780094 at GCKR, the glucokinase regulator gene. The commonly reported genotype letters for end-user literature are CC, CT, and TT.PMC2570409biomarker association · close proxyOrho-Melander et al. reported that rs780094 in the GCKR region was associated with opposite effects on fasting triglycerides and glucose, with the T allele linked to higher triglycerides and lower fasting glucose.PMC2908550biomarker association · loose proxyThe ARIC Study replicated rs780094 T-allele associations with lower fasting glucose, insulin, insulin resistance, and prevalent diabetes, while also reporting higher triglycerides and C-reactive protein in white participants.PMC3720952biomarker association · loose proxyThe HALCyon Programme reviewed rs780094 as one of the GCKR variants tied to metabolic traits and confirmed the closely related functional GCKR signal for triglyceride and glucose measures. This supports conservative biomarker-tendency scoring.

biomarker tendency · CC

GCKR biomarker tendency

Not used for pathway scoring

rs780094 CC has no scored directional claim for GCKR biomarker tendency.

GCKR rs780094 T-containing genotypes are scored as a stronger GCKR-linked biomarker tendency, mainly higher triglycerides with lower fasting glucose in population studies.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs780094 at GCKR, the glucokinase regulator gene. The commonly reported genotype letters for end-user literature are CC, CT, and TT.PMC2570409biomarker association · close proxyOrho-Melander et al. reported that rs780094 in the GCKR region was associated with opposite effects on fasting triglycerides and glucose, with the T allele linked to higher triglycerides and lower fasting glucose.PMC2908550biomarker association · loose proxyThe ARIC Study replicated rs780094 T-allele associations with lower fasting glucose, insulin, insulin resistance, and prevalent diabetes, while also reporting higher triglycerides and C-reactive protein in white participants.PMC3720952biomarker association · loose proxyThe HALCyon Programme reviewed rs780094 as one of the GCKR variants tied to metabolic traits and confirmed the closely related functional GCKR signal for triglyceride and glucose measures. This supports conservative biomarker-tendency scoring.

Common symptoms people report

  • fatigue after carb-heavy meals
  • weight or appetite issues with triglyceride overlap
  • glucose patterns that seem tied to liver and lipid context

Biomarkers to validate

Fasting glucose

Adds direct glycemic context.

Triglycerides

Useful because GCKR often overlaps with hepatic lipid handling.

Fasting insulin

Helps interpret the broader glucose pattern.

Where DNA analysis helps

DNA can flag when hepatic glucose handling deserves attention instead of treating glucose and lipids as separate topics.

Example Insight

Your liver-side glucose regulation may overlap more with triglyceride handling than generic glucose advice suggests.

Suggested validation: fasting glucose plus triglycerides.

What to do next

  • Review triglycerides together with fasting glucose.
  • Compare GCKR with TCF7L2 and IRS1 when glucose patterns feel mixed.
  • Use marker context before assuming one pathway explains everything.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

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Related pages

TCF7L2

TCF7L2 diabetes gene

IRS1

IRS1 insulin signaling gene

Triglycerides

triglycerides and metabolic health

Fasting insulin

fasting insulin and metabolism

Glucose regulation pathway

glucose regulation pathway

Lipid transport pathway

lipid transport pathway

Genetic test for weight loss Europe

genetic test for weight loss Europe

Related symptom angle

Fatigue after eating carbs

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