What is the ZMIZ1 gene?
ZMIZ1 is a regulatory gene linked to immune susceptibility signals in celiac GWAS evidence. It is not a gluten digestion gene.
How ZMIZ1 affects metabolism
A ZMIZ1 signal can add modest immune-risk context but should not be used as a standalone explanation for symptoms.
What happens when ZMIZ1 is altered
A ZMIZ1 signal needs HLA, serology, symptoms, and clinician context before it matters in practice.
Curated SNP evidence for ZMIZ1
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
ZMIZ1 currently has 1 curated SNPs, 1 claim-level scores, and 1 claims eligible for pathway scoring.
Open the sample reportrs1250552ZMIZ1 celiac susceptibility signal1 claims · 3 study rows
disease trait · AA
Non-HLA ZMIZ1 celiac susceptibility context
rs1250552 AA carries the GWAS Catalog celiac disease risk A allele at the ZMIZ1 immune locus.
ZMIZ1 rs1250552 AA is scored as small non-HLA celiac susceptibility context.
Show study evidence
Common symptoms people report
- digestive symptoms where celiac testing is relevant
- family context around autoimmune disease
- genetic immune-risk findings that need prioritization
Biomarkers to validate
tTG-IgA with total IgA
Primary serology context.
EMA or DGP context
Adds follow-up context when clinically appropriate.
Formal HLA-DQ typing
Clarifies whether the main celiac-compatible HLA background is present.
Where DNA analysis helps
DNA helps place ZMIZ1 inside a broader celiac immune-risk pattern rather than treating it as a yes/no answer.
Example interpretation
ZMIZ1 may add useful context when its SNP evidence lines up with the broader pathway signal.
Suggested validation: celiac serology and HLA-DQ context.
What to do next
- Keep ZMIZ1 secondary to HLA-DQ and serology.
- Avoid gluten restriction decisions from this gene alone.
- Use clinical testing if celiac disease is a real concern.
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