What is the SH2B3 gene?
SH2B3 participates in immune and hematopoietic signaling. Here it is used only as non-HLA susceptibility context.
How SH2B3 affects metabolism
A SH2B3 signal may add to immune-risk background but does not identify gluten sensitivity or diagnose celiac disease.
What happens when SH2B3 is altered
SH2B3 should stay secondary to HLA-DQ background, serology, symptoms, and clinician evaluation.
Curated SNP evidence for SH2B3
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
SH2B3 currently has 1 curated SNPs, 1 claim-level scores, and 1 claims eligible for pathway scoring.
Open the sample reportrs3184504SH2B3 celiac susceptibility signal1 claims · 3 study rows
disease trait · CT
Non-HLA SH2B3 celiac susceptibility context
rs3184504 CT carries one GWAS Catalog celiac disease risk C allele at the SH2B3 immune-signaling locus.
SH2B3 rs3184504 CT is scored as small non-HLA celiac susceptibility context.
Show study evidence
Common symptoms people report
- digestive symptoms with autoimmune context
- family context around immune conditions
- small-effect celiac SNP findings
Biomarkers to validate
tTG-IgA with total IgA
Primary celiac screening context.
EMA or DGP context
Useful when clinician-directed follow-up is needed.
Formal HLA-DQ typing
Clarifies the main genetic celiac background.
Where DNA analysis helps
DNA helps show whether non-HLA immune context is present, but it does not replace diagnostic testing.
Example interpretation
SH2B3 may add useful context when its SNP evidence lines up with the broader pathway signal.
Suggested validation: celiac serology and clinical context.
What to do next
- Keep SH2B3 as low-impact context.
- Use serology before dietary conclusions.
- Interpret with HLA and symptoms, not alone.
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