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Primary topic: MTNR1B glucose circadian gene

MTNR1B Gene and Metabolism: What It Means for Your Body

MTNR1B becomes relevant when fasting glucose and circadian timing seem more connected than expected.

What is the MTNR1B gene?

MTNR1B is part of melatonin signaling, which means it links circadian timing with glucose regulation and beta-cell behavior.

How MTNR1B affects metabolism

If MTNR1B-related signaling is less favorable, fasting glucose patterns may become less forgiving when sleep timing and meal timing are inconsistent.

What happens when MTNR1B is altered

Altered MTNR1B function does not mean sleep is the whole story, but it does increase the value of reviewing circadian habits alongside glucose markers.

Curated SNP evidence for MTNR1B

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Glucose

Evidence-backed report connection

MTNR1B currently has 2 curated SNPs, 6 claim-level scores, and 4 claims eligible for pathway scoring.

Open the sample report
rs10830963MTNR1B fasting-glucose signal3 claims · 9 study rows

biomarker tendency · GG

MTNR1B biomarker tendency

Strong

rs10830963 GG is associated with increased MTNR1B biomarker tendency.

MTNR1B rs10830963 is scored as a glycemic-response biomarker tendency for G-containing genotypes, stronger for GG than CG.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs10830963 in MTNR1B and annotate common C and G alleles, with intronic transcript annotations. This supports using CC, CG, and GG genotype letters for this simplified record.PubMed 19324940biomarker association · close proxyA study of 19,605 Europeans reported that the rs10830963 G allele was associated with higher fasting plasma glucose, impaired fasting glycemia, type 2 diabetes association, and lower glucose-stimulated insulin release. This supports a G-allele-dose biomarker-tendency score.PubMed 19060908gwas · loose proxyA Nature Genetics study reported that the MTNR1B risk genotype was associated with impaired early insulin response and increased MTNR1B expression in human islets. This supports a glucose-regulation biomarker tendency rather than a standalone diagnosis.

biomarker tendency · CG

MTNR1B biomarker tendency

Moderate

rs10830963 CG is associated with increased MTNR1B biomarker tendency.

MTNR1B rs10830963 is scored as a glycemic-response biomarker tendency for G-containing genotypes, stronger for GG than CG.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs10830963 in MTNR1B and annotate common C and G alleles, with intronic transcript annotations. This supports using CC, CG, and GG genotype letters for this simplified record.PubMed 19324940biomarker association · close proxyA study of 19,605 Europeans reported that the rs10830963 G allele was associated with higher fasting plasma glucose, impaired fasting glycemia, type 2 diabetes association, and lower glucose-stimulated insulin release. This supports a G-allele-dose biomarker-tendency score.PubMed 19060908gwas · loose proxyA Nature Genetics study reported that the MTNR1B risk genotype was associated with impaired early insulin response and increased MTNR1B expression in human islets. This supports a glucose-regulation biomarker tendency rather than a standalone diagnosis.

biomarker tendency · CC

MTNR1B biomarker tendency

Not used for pathway scoring

rs10830963 CC has no scored directional claim for MTNR1B biomarker tendency.

MTNR1B rs10830963 is scored as a glycemic-response biomarker tendency for G-containing genotypes, stronger for GG than CG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs10830963 in MTNR1B and annotate common C and G alleles, with intronic transcript annotations. This supports using CC, CG, and GG genotype letters for this simplified record.PubMed 19324940biomarker association · close proxyA study of 19,605 Europeans reported that the rs10830963 G allele was associated with higher fasting plasma glucose, impaired fasting glycemia, type 2 diabetes association, and lower glucose-stimulated insulin release. This supports a G-allele-dose biomarker-tendency score.PubMed 19060908gwas · loose proxyA Nature Genetics study reported that the MTNR1B risk genotype was associated with impaired early insulin response and increased MTNR1B expression in human islets. This supports a glucose-regulation biomarker tendency rather than a standalone diagnosis.
rs1387153MTNR1B supporting signal3 claims · 9 study rows

biomarker tendency · TT

MTNR1B biomarker tendency

Moderate

rs1387153 TT is associated with increased MTNR1B biomarker tendency.

MTNR1B-nearby rs1387153 is scored as a modest fasting-glucose biomarker tendency for T-containing genotypes, stronger for TT than CT.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data annotate rs1387153 as a common C/T variant on chromosome 11 near the MTNR1B locus. This supports using CC, CT, and TT genotype letters for this simplified record.PubMed 19060909biomarker association · close proxyA Nature Genetics study identified rs1387153 near MTNR1B as a fasting plasma glucose signal and reported that the T allele was associated with higher fasting glucose and type 2 diabetes association estimates. This supports a T-allele-dose biomarker-tendency score.PubMed 19060907biomarker association · close proxyA companion MTNR1B fasting-glucose study reported strong association at the MTNR1B locus and highlighted rs10830963 as the strongest signal, while noting rs1387153 among exchanged MTNR1B signals. This supports treating rs1387153 as a nearby biomarker signal with modest certainty.

biomarker tendency · CT

MTNR1B biomarker tendency

Moderate

rs1387153 CT is associated with increased MTNR1B biomarker tendency.

MTNR1B-nearby rs1387153 is scored as a modest fasting-glucose biomarker tendency for T-containing genotypes, stronger for TT than CT.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data annotate rs1387153 as a common C/T variant on chromosome 11 near the MTNR1B locus. This supports using CC, CT, and TT genotype letters for this simplified record.PubMed 19060909biomarker association · close proxyA Nature Genetics study identified rs1387153 near MTNR1B as a fasting plasma glucose signal and reported that the T allele was associated with higher fasting glucose and type 2 diabetes association estimates. This supports a T-allele-dose biomarker-tendency score.PubMed 19060907biomarker association · close proxyA companion MTNR1B fasting-glucose study reported strong association at the MTNR1B locus and highlighted rs10830963 as the strongest signal, while noting rs1387153 among exchanged MTNR1B signals. This supports treating rs1387153 as a nearby biomarker signal with modest certainty.

biomarker tendency · CC

MTNR1B biomarker tendency

Not used for pathway scoring

rs1387153 CC has no scored directional claim for MTNR1B biomarker tendency.

MTNR1B-nearby rs1387153 is scored as a modest fasting-glucose biomarker tendency for T-containing genotypes, stronger for TT than CT.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data annotate rs1387153 as a common C/T variant on chromosome 11 near the MTNR1B locus. This supports using CC, CT, and TT genotype letters for this simplified record.PubMed 19060909biomarker association · close proxyA Nature Genetics study identified rs1387153 near MTNR1B as a fasting plasma glucose signal and reported that the T allele was associated with higher fasting glucose and type 2 diabetes association estimates. This supports a T-allele-dose biomarker-tendency score.PubMed 19060907biomarker association · close proxyA companion MTNR1B fasting-glucose study reported strong association at the MTNR1B locus and highlighted rs10830963 as the strongest signal, while noting rs1387153 among exchanged MTNR1B signals. This supports treating rs1387153 as a nearby biomarker signal with modest certainty.

Common symptoms people report

  • higher fasting glucose despite mixed symptoms
  • carb response that worsens with poor sleep timing
  • difficulty separating circadian strain from glucose strain

Biomarkers to validate

Fasting glucose

Useful for the baseline signal MTNR1B often overlaps with.

HbA1c

Adds broader glycemic context.

Sleep and meal timing tracking

Practical context when circadian effects may matter.

Where DNA analysis helps

DNA can help show when circadian glucose effects deserve more attention than generic glucose advice provides.

Example Insight

Your glucose pattern may be more sensitive to circadian disruption than expected.

Suggested validation: fasting glucose plus sleep-timing review.

What to do next

  • Compare fasting glucose with sleep timing and meal timing.
  • Review MTNR1B with TCF7L2 and SLC30A8 when beta-cell questions overlap.
  • Use behavior and biomarker context before assuming a fixed trait.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

Get My DNA Report

Related pages

TCF7L2

TCF7L2 diabetes gene

SLC30A8

SLC30A8 insulin gene

Fasting insulin

fasting insulin and metabolism

Triglycerides

triglycerides and metabolic health

Glucose regulation pathway

glucose regulation pathway

Genetic test for weight loss Europe

genetic test for weight loss Europe

Related symptom angle

Fatigue after eating carbs

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