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Primary topic: TF gene DNA analysis

TF Gene and Metabolism: What It Can Mean in a Pathway Report

TF becomes more useful when iron handling looks like a meaningful follow-up area instead of just background context.

What is the TF gene?

TF contributes to iron transport capacity across the bloodstream. That makes it more useful as part of a pathway view than as an isolated SNP call.

How TF affects metabolism

If TF-related support is less favorable, the pathway can look more pressured under load and the linked biomarkers become more useful to validate directly.

What happens when TF is altered

An altered TF pattern does not diagnose anything on its own, but it does change which follow-up markers deserve attention first.

Curated SNP evidence for TF

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Iron handling

Evidence-backed report connection

TF currently has 2 curated SNPs, 12 claim-level scores, and 3 claims eligible for pathway scoring.

Open the sample report
rs1799852TF supporting signal6 claims · 18 study rows

biomarker tendency · TT

TF biomarker tendency

Moderate

rs1799852 TT is associated with reduced TF biomarker tendency.

TF rs1799852 is scored as a modest tendency toward lower serum transferrin for T-containing C/T genotypes, strongest for TT.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1799852 in TF and lists C, A, and T alleles. The T allele is annotated as a synonymous TF coding change in the shown transcripts, while the A allele is a rarer missense annotation; this supports treating the file as a transferrin biomarker-tendency record rather than an enzyme-activity record.PMC2668053gwas · close proxyA genome-wide study of iron markers reported rs1799852 as one of the independent TF variants explaining serum transferrin variation. This supports a cautious serum-transferrin tendency for the source-supported T allele.PMC3195693biomarker association · close proxyAn association study in menstruating women reported that the T allele of rs1799852 had a reducing effect on serum transferrin levels. This supports lower biomarker-tendency scoring for CT and TT genotypes, with TT kept cautious because the study did not observe that genotype.

biomarker tendency · CT

TF biomarker tendency

Not used for pathway scoring

rs1799852 CT is associated with reduced TF biomarker tendency.

TF rs1799852 is scored as a modest tendency toward lower serum transferrin for T-containing C/T genotypes, strongest for TT.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1799852 in TF and lists C, A, and T alleles. The T allele is annotated as a synonymous TF coding change in the shown transcripts, while the A allele is a rarer missense annotation; this supports treating the file as a transferrin biomarker-tendency record rather than an enzyme-activity record.PMC2668053gwas · close proxyA genome-wide study of iron markers reported rs1799852 as one of the independent TF variants explaining serum transferrin variation. This supports a cautious serum-transferrin tendency for the source-supported T allele.PMC3195693biomarker association · close proxyAn association study in menstruating women reported that the T allele of rs1799852 had a reducing effect on serum transferrin levels. This supports lower biomarker-tendency scoring for CT and TT genotypes, with TT kept cautious because the study did not observe that genotype.

biomarker tendency · AA

TF biomarker tendency

Not used for pathway scoring

rs1799852 AA has no scored directional claim for TF biomarker tendency.

TF rs1799852 is scored as a modest tendency toward lower serum transferrin for T-containing C/T genotypes, strongest for TT.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1799852 in TF and lists C, A, and T alleles. The T allele is annotated as a synonymous TF coding change in the shown transcripts, while the A allele is a rarer missense annotation; this supports treating the file as a transferrin biomarker-tendency record rather than an enzyme-activity record.PMC2668053gwas · close proxyA genome-wide study of iron markers reported rs1799852 as one of the independent TF variants explaining serum transferrin variation. This supports a cautious serum-transferrin tendency for the source-supported T allele.PMC3195693biomarker association · close proxyAn association study in menstruating women reported that the T allele of rs1799852 had a reducing effect on serum transferrin levels. This supports lower biomarker-tendency scoring for CT and TT genotypes, with TT kept cautious because the study did not observe that genotype.

biomarker tendency · AC

TF biomarker tendency

Not used for pathway scoring

rs1799852 AC has no scored directional claim for TF biomarker tendency.

TF rs1799852 is scored as a modest tendency toward lower serum transferrin for T-containing C/T genotypes, strongest for TT.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1799852 in TF and lists C, A, and T alleles. The T allele is annotated as a synonymous TF coding change in the shown transcripts, while the A allele is a rarer missense annotation; this supports treating the file as a transferrin biomarker-tendency record rather than an enzyme-activity record.PMC2668053gwas · close proxyA genome-wide study of iron markers reported rs1799852 as one of the independent TF variants explaining serum transferrin variation. This supports a cautious serum-transferrin tendency for the source-supported T allele.PMC3195693biomarker association · close proxyAn association study in menstruating women reported that the T allele of rs1799852 had a reducing effect on serum transferrin levels. This supports lower biomarker-tendency scoring for CT and TT genotypes, with TT kept cautious because the study did not observe that genotype.

biomarker tendency · AT

TF biomarker tendency

Not used for pathway scoring

rs1799852 AT has no scored directional claim for TF biomarker tendency.

TF rs1799852 is scored as a modest tendency toward lower serum transferrin for T-containing C/T genotypes, strongest for TT.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1799852 in TF and lists C, A, and T alleles. The T allele is annotated as a synonymous TF coding change in the shown transcripts, while the A allele is a rarer missense annotation; this supports treating the file as a transferrin biomarker-tendency record rather than an enzyme-activity record.PMC2668053gwas · close proxyA genome-wide study of iron markers reported rs1799852 as one of the independent TF variants explaining serum transferrin variation. This supports a cautious serum-transferrin tendency for the source-supported T allele.PMC3195693biomarker association · close proxyAn association study in menstruating women reported that the T allele of rs1799852 had a reducing effect on serum transferrin levels. This supports lower biomarker-tendency scoring for CT and TT genotypes, with TT kept cautious because the study did not observe that genotype.

biomarker tendency · CC

TF biomarker tendency

Not used for pathway scoring

rs1799852 CC has no scored directional claim for TF biomarker tendency.

TF rs1799852 is scored as a modest tendency toward lower serum transferrin for T-containing C/T genotypes, strongest for TT.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs1799852 in TF and lists C, A, and T alleles. The T allele is annotated as a synonymous TF coding change in the shown transcripts, while the A allele is a rarer missense annotation; this supports treating the file as a transferrin biomarker-tendency record rather than an enzyme-activity record.PMC2668053gwas · close proxyA genome-wide study of iron markers reported rs1799852 as one of the independent TF variants explaining serum transferrin variation. This supports a cautious serum-transferrin tendency for the source-supported T allele.PMC3195693biomarker association · close proxyAn association study in menstruating women reported that the T allele of rs1799852 had a reducing effect on serum transferrin levels. This supports lower biomarker-tendency scoring for CT and TT genotypes, with TT kept cautious because the study did not observe that genotype.
rs3811647TF supporting signal6 claims · 18 study rows

biomarker tendency · AA

TF biomarker tendency

Strong

rs3811647 AA is associated with increased TF biomarker tendency.

For common A/G calls, rs3811647 is scored as a tendency toward higher transferrin-related iron biomarkers with more A copies: AA strongest, AG intermediate, and GG not scored as increased.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3811647 in TF, the transferrin gene, and list A, C, and G as observed letters for this marker.PMC2668053gwas · close proxyBenyamin and colleagues reported that rs3811647 in TF was strongly associated with serum transferrin in a genome-wide study, with each A allele increasing serum transferrin in an additive model. The effect on transferrin saturation and ferritin was much smaller.Evidence 3gwas · close proxyAn independent iron-deficiency GWAS replicated an association between rs3811647 in the TF gene and total iron-binding capacity, supporting a transferrin-related biomarker tendency rather than a disease diagnosis.

biomarker tendency · AG

TF biomarker tendency

Moderate

rs3811647 AG is associated with increased TF biomarker tendency.

For common A/G calls, rs3811647 is scored as a tendency toward higher transferrin-related iron biomarkers with more A copies: AA strongest, AG intermediate, and GG not scored as increased.

Likely effectHigher biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3811647 in TF, the transferrin gene, and list A, C, and G as observed letters for this marker.PMC2668053gwas · close proxyBenyamin and colleagues reported that rs3811647 in TF was strongly associated with serum transferrin in a genome-wide study, with each A allele increasing serum transferrin in an additive model. The effect on transferrin saturation and ferritin was much smaller.Evidence 3gwas · close proxyAn independent iron-deficiency GWAS replicated an association between rs3811647 in the TF gene and total iron-binding capacity, supporting a transferrin-related biomarker tendency rather than a disease diagnosis.

biomarker tendency · AC

TF biomarker tendency

Not used for pathway scoring

rs3811647 AC has no scored directional claim for TF biomarker tendency.

For common A/G calls, rs3811647 is scored as a tendency toward higher transferrin-related iron biomarkers with more A copies: AA strongest, AG intermediate, and GG not scored as increased.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3811647 in TF, the transferrin gene, and list A, C, and G as observed letters for this marker.PMC2668053gwas · close proxyBenyamin and colleagues reported that rs3811647 in TF was strongly associated with serum transferrin in a genome-wide study, with each A allele increasing serum transferrin in an additive model. The effect on transferrin saturation and ferritin was much smaller.Evidence 3gwas · close proxyAn independent iron-deficiency GWAS replicated an association between rs3811647 in the TF gene and total iron-binding capacity, supporting a transferrin-related biomarker tendency rather than a disease diagnosis.

biomarker tendency · CC

TF biomarker tendency

Not used for pathway scoring

rs3811647 CC has no scored directional claim for TF biomarker tendency.

For common A/G calls, rs3811647 is scored as a tendency toward higher transferrin-related iron biomarkers with more A copies: AA strongest, AG intermediate, and GG not scored as increased.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3811647 in TF, the transferrin gene, and list A, C, and G as observed letters for this marker.PMC2668053gwas · close proxyBenyamin and colleagues reported that rs3811647 in TF was strongly associated with serum transferrin in a genome-wide study, with each A allele increasing serum transferrin in an additive model. The effect on transferrin saturation and ferritin was much smaller.Evidence 3gwas · close proxyAn independent iron-deficiency GWAS replicated an association between rs3811647 in the TF gene and total iron-binding capacity, supporting a transferrin-related biomarker tendency rather than a disease diagnosis.

biomarker tendency · CG

TF biomarker tendency

Not used for pathway scoring

rs3811647 CG has no scored directional claim for TF biomarker tendency.

For common A/G calls, rs3811647 is scored as a tendency toward higher transferrin-related iron biomarkers with more A copies: AA strongest, AG intermediate, and GG not scored as increased.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3811647 in TF, the transferrin gene, and list A, C, and G as observed letters for this marker.PMC2668053gwas · close proxyBenyamin and colleagues reported that rs3811647 in TF was strongly associated with serum transferrin in a genome-wide study, with each A allele increasing serum transferrin in an additive model. The effect on transferrin saturation and ferritin was much smaller.Evidence 3gwas · close proxyAn independent iron-deficiency GWAS replicated an association between rs3811647 in the TF gene and total iron-binding capacity, supporting a transferrin-related biomarker tendency rather than a disease diagnosis.

biomarker tendency · GG

TF biomarker tendency

Not used for pathway scoring

rs3811647 GG has no scored directional claim for TF biomarker tendency.

For common A/G calls, rs3811647 is scored as a tendency toward higher transferrin-related iron biomarkers with more A copies: AA strongest, AG intermediate, and GG not scored as increased.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3811647 in TF, the transferrin gene, and list A, C, and G as observed letters for this marker.PMC2668053gwas · close proxyBenyamin and colleagues reported that rs3811647 in TF was strongly associated with serum transferrin in a genome-wide study, with each A allele increasing serum transferrin in an additive model. The effect on transferrin saturation and ferritin was much smaller.Evidence 3gwas · close proxyAn independent iron-deficiency GWAS replicated an association between rs3811647 in the TF gene and total iron-binding capacity, supporting a transferrin-related biomarker tendency rather than a disease diagnosis.

Common symptoms people report

  • iron handling can overlap with more persistent symptom patterns
  • marker-driven follow-up may matter more than generic advice
  • mixed responses can make the pathway easier to miss without structured review

Biomarkers to validate

Iron saturation

Primary follow-up marker for TF inside iron handling.

Related pathway markers

Useful when the pathway needs to be validated as a system rather than as one variant.

Where DNA analysis helps

DNA helps decide whether TF should move iron handling higher on the follow-up list before broad interventions are assumed.

Example interpretation

TF can strengthen the case for iron handling follow-up when the rest of the pathway points in a similar direction.

Suggested validation: Iron saturation.

What to do next

  • Use Iron saturation and pathway context before assuming the gene matters in practice.
  • Read TF alongside the related genes in the same pathway instead of as a standalone result.

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Related pages

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HFE gene DNA analysis

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Ferritin and iron storage DNA follow-up

Ferritin and inflammatory context

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Iron handling and storage pathway

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How accurate are DNA metabolism reports?

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23andMe vs Metastate metabolism report

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Related symptom angle

Low energy metabolism causes

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