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Primary topic: CETP lipid transport gene

CETP Gene and Metabolism: What It Means for Your Body

CETP matters when lipoprotein exchange and HDL-triglyceride context deserve more attention than total cholesterol alone.

What is the CETP gene?

CETP helps move cholesteryl esters and triglycerides between lipoproteins. That makes it relevant to particle balance rather than only one isolated lipid number.

How CETP affects metabolism

If CETP-related exchange is less favorable, HDL and triglyceride patterns can become harder to interpret at a glance. That is why particle-aware follow-up matters.

What happens when CETP is altered

Altered CETP signaling does not define risk on its own, but it increases the value of reading ApoB, triglycerides, and HDL context together.

Curated SNP evidence for CETP

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Lipids

Evidence-backed report connection

CETP currently has 4 curated SNPs, 8 claim-level scores, and 6 claims eligible for pathway scoring.

Open the sample report
rs1800775CETP -629C>A1 claims · 2 study rows

enzyme activity · A

CETP activity tendency

Moderate

rs1800775 A / CETP -629A is associated with lower CETP promoter activity, CETP mass/activity, and higher HDL-C tendency.

CETP rs1800775 A is staged as a lower CETP activity allele with downstream HDL-remodeling biomarker effects.

Likely effectLower enzyme activity signal
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
PMID 10669650functional assay · directThe checked promoter-function study reports that the CETP -629A allele is associated with lower CETP mass and higher HDL-C, and that A-containing promoter constructs showed lower luciferase activity in HepG2 cells.PMID 18560005biomarker association · directThe checked CETP genotype meta-analysis includes -629C>A / rs1800775 and reports a pattern similar to TaqIB: alleles associated with lower CETP mass/activity and higher HDL-C, with per-allele coronary-risk estimates kept out of this claim.
rs3764261CETP HDL-C supporting signal1 claims · 2 study rows

biomarker tendency · CC

CETP-linked HDL cholesterol tendency

Moderate

rs3764261 CC carries two CETP rs3764261 C alleles and is associated with lower HDL cholesterol tendency than A-containing genotypes.

CETP rs3764261 CC is staged as a lower-HDL-C tendency signal at a CETP HDL-remodeling locus.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
POUNDS LOST and DIRECT CETP diet-intervention studybiomarker association · directThe checked randomized diet-intervention source describes rs3764261 as an established HDL-C SNP where the A allele raises HDL-C and the HDL-decreasing allele is associated with higher LDL-C and triglycerides. The sample CC genotype has two HDL-decreasing C alleles.PMID 29699816 SNAP rs3764261 HDL-C studybiomarker association · directThe checked PubMed abstract reports that each copy of the HDL-C risk C allele at CETP rs3764261 was associated with lower baseline HDL-C. This directly supports the lower-HDL-C direction for the sample CC genotype.
rs5882CETP supporting signal3 claims · 12 study rows

transport activity · GG

CETP transport activity

Moderate

rs5882 GG is associated with reduced CETP transport activity.

CETP rs5882 G-containing genotypes are scored as a lower CETP transport-activity tendency, with GG scored stronger than AG.

Likely effectLower transport signal
Signal sizeModerate signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs5882 in CETP, the cholesteryl ester transfer protein gene. The common literature coding for this SNP uses A and G genotype letters.PubMed 17568242biomarker association · loose proxyThe Rotterdam Study reported that the CETP I405V polymorphism was associated with increased HDL-C in VV carriers. This supports a lipid-marker tendency for the valine-linked genotype, while not proving a fixed health outcome.PubMed 10619997functional assay · directA study of CETP polymorphisms in men reported lower plasma CETP activity for VV405 compared with II405. This supports scoring the G-linked valine allele as a lower CETP transport-activity tendency.PubMed 17196207other · loose proxyTeran-Garcia et al. studied rs5882, also called I405V, and reported genotype-related differences in HDL-C and HDL subfractions during an overfeeding study. This supports keeping certainty moderate because diet and energy balance can modify the observed lipid pattern.

transport activity · AG

CETP transport activity

Moderate

rs5882 AG is associated with reduced CETP transport activity.

CETP rs5882 G-containing genotypes are scored as a lower CETP transport-activity tendency, with GG scored stronger than AG.

Likely effectLower transport signal
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs5882 in CETP, the cholesteryl ester transfer protein gene. The common literature coding for this SNP uses A and G genotype letters.PubMed 17568242biomarker association · loose proxyThe Rotterdam Study reported that the CETP I405V polymorphism was associated with increased HDL-C in VV carriers. This supports a lipid-marker tendency for the valine-linked genotype, while not proving a fixed health outcome.PubMed 10619997functional assay · directA study of CETP polymorphisms in men reported lower plasma CETP activity for VV405 compared with II405. This supports scoring the G-linked valine allele as a lower CETP transport-activity tendency.PubMed 17196207other · loose proxyTeran-Garcia et al. studied rs5882, also called I405V, and reported genotype-related differences in HDL-C and HDL subfractions during an overfeeding study. This supports keeping certainty moderate because diet and energy balance can modify the observed lipid pattern.

transport activity · AA

CETP transport activity

Not used for pathway scoring

rs5882 AA has no scored directional claim for CETP transport activity.

CETP rs5882 G-containing genotypes are scored as a lower CETP transport-activity tendency, with GG scored stronger than AG.

Likely effectNo clear transport signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs5882 in CETP, the cholesteryl ester transfer protein gene. The common literature coding for this SNP uses A and G genotype letters.PubMed 17568242biomarker association · loose proxyThe Rotterdam Study reported that the CETP I405V polymorphism was associated with increased HDL-C in VV carriers. This supports a lipid-marker tendency for the valine-linked genotype, while not proving a fixed health outcome.PubMed 10619997functional assay · directA study of CETP polymorphisms in men reported lower plasma CETP activity for VV405 compared with II405. This supports scoring the G-linked valine allele as a lower CETP transport-activity tendency.PubMed 17196207other · loose proxyTeran-Garcia et al. studied rs5882, also called I405V, and reported genotype-related differences in HDL-C and HDL subfractions during an overfeeding study. This supports keeping certainty moderate because diet and energy balance can modify the observed lipid pattern.
rs708272TaqIB3 claims · 9 study rows

transport activity · AA

CETP transport activity

Strong

rs708272 AA is associated with reduced CETP transport activity.

CETP rs708272 A-containing genotypes are scored as a lower CETP transport-activity tendency, with the strongest score for AA and an intermediate score for AG.

Likely effectLower transport signal
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs708272 in CETP, the cholesteryl ester transfer protein gene. The common literature coding for this SNP uses A and G genotype letters.Evidence 2biomarker association · loose proxyRahimi et al. describe CETP TaqIB rs708272 as a G-to-A intron 1 change. In this naming system, the A-linked B2 allele lacks the restriction site and has been associated with higher HDL-C and lower CETP activity and levels.Evidence 3biomarker association · directA Tehran Lipid and Glucose Study subgroup found the highest HDL-C in B2B2 participants and lower HDL-C in B1 carriers. This supports scoring A-containing rs708272 genotypes as a lower CETP transport-activity tendency, not as a disease diagnosis.

transport activity · AG

CETP transport activity

Moderate

rs708272 AG is associated with reduced CETP transport activity.

CETP rs708272 A-containing genotypes are scored as a lower CETP transport-activity tendency, with the strongest score for AA and an intermediate score for AG.

Likely effectLower transport signal
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs708272 in CETP, the cholesteryl ester transfer protein gene. The common literature coding for this SNP uses A and G genotype letters.Evidence 2biomarker association · loose proxyRahimi et al. describe CETP TaqIB rs708272 as a G-to-A intron 1 change. In this naming system, the A-linked B2 allele lacks the restriction site and has been associated with higher HDL-C and lower CETP activity and levels.Evidence 3biomarker association · directA Tehran Lipid and Glucose Study subgroup found the highest HDL-C in B2B2 participants and lower HDL-C in B1 carriers. This supports scoring A-containing rs708272 genotypes as a lower CETP transport-activity tendency, not as a disease diagnosis.

transport activity · GG

CETP transport activity

Not used for pathway scoring

rs708272 GG has no scored directional claim for CETP transport activity.

CETP rs708272 A-containing genotypes are scored as a lower CETP transport-activity tendency, with the strongest score for AA and an intermediate score for AG.

Likely effectNo clear transport signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs708272 in CETP, the cholesteryl ester transfer protein gene. The common literature coding for this SNP uses A and G genotype letters.Evidence 2biomarker association · loose proxyRahimi et al. describe CETP TaqIB rs708272 as a G-to-A intron 1 change. In this naming system, the A-linked B2 allele lacks the restriction site and has been associated with higher HDL-C and lower CETP activity and levels.Evidence 3biomarker association · directA Tehran Lipid and Glucose Study subgroup found the highest HDL-C in B2B2 participants and lower HDL-C in B1 carriers. This supports scoring A-containing rs708272 genotypes as a lower CETP transport-activity tendency, not as a disease diagnosis.

Common symptoms people report

  • unclear lipid patterns despite reasonable habits
  • family context around cholesterol issues
  • difficulty interpreting HDL and triglycerides together

Biomarkers to validate

ApoB

High-value particle follow-up.

Triglycerides

Useful because CETP overlaps with triglyceride exchange.

HDL context

Adds interpretive context rather than acting alone.

Where DNA analysis helps

DNA helps show when lipoprotein-exchange questions deserve more attention than generic cholesterol summaries provide.

Example Insight

Your lipid-transport picture may deserve a particle-level review because exchange patterns can hide inside familiar cholesterol labels.

Suggested validation: ApoB plus triglycerides.

What to do next

  • Use ApoB and triglycerides before relying on HDL alone.
  • Compare CETP with APOE and LDLR when transport questions overlap.
  • Treat the gene as context, not a standalone answer.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

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