What is the MTR gene?
MTR encodes methionine synthase, the enzyme that uses methyl-B12 to move homocysteine back toward methionine. That makes it central to methylation flow rather than a peripheral nutrient detail.
How MTR affects metabolism
If MTR-related throughput is lower, methylation support can stall even when folate intake looks reasonable. In practice this overlaps with homocysteine, B12 handling, and one-carbon resilience.
What happens when MTR is altered
Altered MTR function does not prove deficiency, but it raises the value of checking functional B12 and methylation markers before assuming the pathway is fine.
Tracked SNPs used for MTR
Methionine synthase support inside B12-dependent remethylation.
The directional notes below are shared between the public gene pages and the tracked SNP report so the same SNP list drives both surfaces.
| SNP | Alias | Why it is tracked | Effect allele | Directional note | Confidence | Linked pathway |
|---|---|---|---|---|---|---|
| rs10925235 | MTR supporting signal | Supporting MTR SNP used in broader methylation review. | — | No directional hint published yet. | — | Methylation, B12 transport |
| rs1805087 | A2756G | Common MTR variant reviewed in B12-dependent remethylation context. | G | Often reviewed as lower remethylation support when B12-dependent methylation looks uneven. | moderate | Methylation, B12 transport |
Common symptoms people report
- brain fog with unclear B12 context
- fatigue despite reasonable nutrient intake
- homocysteine concerns that do not fit a simple folate-only explanation
Biomarkers to validate
Homocysteine
Useful for checking whether remethylation support looks pressured.
Methylmalonic acid
Adds context for functional B12 sufficiency.
Holotranscobalamin
Helpful when transport and recycling questions overlap.
Where DNA analysis helps
DNA helps show whether methionine synthase deserves attention inside a broader methylation or B12 review. The value is in prioritizing follow-up markers, not diagnosing from genetics alone.
Example Insight
Your methionine synthase step may deserve follow-up because B12-dependent methylation support does not always fail at the same place.
Suggested validation: homocysteine plus methylmalonic acid.
What to do next
- Check homocysteine and methylmalonic acid before assuming MTR is limiting.
- Review MTR together with MTRR and TCN2 when B12 support looks uneven.
- Use functional markers before changing supplement strategy aggressively.
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