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Primary topic: GSS gene DNA analysis

GSS Gene and Metabolism: What It Can Mean in a Pathway Report

GSS becomes more useful when sulfur / transsulfuration looks like a meaningful follow-up area instead of just background context.

What is the GSS gene?

GSS contributes to final glutathione synthesis after cysteine availability. That makes it more useful as part of a pathway view than as an isolated SNP call.

How GSS affects metabolism

If GSS-related support is less favorable, the pathway can look more pressured under load and the linked biomarkers become more useful to validate directly.

What happens when GSS is altered

An altered GSS pattern does not diagnose anything on its own, but it does change which follow-up markers deserve attention first.

Curated SNP evidence for GSS

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Sulfur / transsulfuration

Evidence-backed report connection

GSS currently has 2 curated SNPs, 13 claim-level scores, and 0 claims eligible for pathway scoring.

Open the sample report
rs13041792GSS supporting signal3 claims · 6 study rows

unknown · AA

GSS unscored target

Not used for pathway scoring

rs13041792 AA has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs13041792. Treat AA, AG, and GG as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs13041792 as a single-nucleotide variant with A and G alleles on the preferred placement. NCBI annotation places it near GSS and also near MYH7B, so gene-level interpretation should be cautious.PMC10003739review · loose proxyA review of redox-homeostasis genetics describes rs13041792 near the GSS transcription start, notes associations with metabolic traits in some studies, and also notes that GTEx data did not show a GSS expression effect. This supports keeping the simplified genotype effect neutral rather than assigning enzyme activity.

unknown · AG

GSS unscored target

Not used for pathway scoring

rs13041792 AG has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs13041792. Treat AA, AG, and GG as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs13041792 as a single-nucleotide variant with A and G alleles on the preferred placement. NCBI annotation places it near GSS and also near MYH7B, so gene-level interpretation should be cautious.PMC10003739review · loose proxyA review of redox-homeostasis genetics describes rs13041792 near the GSS transcription start, notes associations with metabolic traits in some studies, and also notes that GTEx data did not show a GSS expression effect. This supports keeping the simplified genotype effect neutral rather than assigning enzyme activity.

unknown · GG

GSS unscored target

Not used for pathway scoring

rs13041792 GG has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs13041792. Treat AA, AG, and GG as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs13041792 as a single-nucleotide variant with A and G alleles on the preferred placement. NCBI annotation places it near GSS and also near MYH7B, so gene-level interpretation should be cautious.PMC10003739review · loose proxyA review of redox-homeostasis genetics describes rs13041792 near the GSS transcription start, notes associations with metabolic traits in some studies, and also notes that GTEx data did not show a GSS expression effect. This supports keeping the simplified genotype effect neutral rather than assigning enzyme activity.
rs6088659GSS supporting signal10 claims · 20 study rows

unknown · AA

GSS unscored target

Not used for pathway scoring

rs6088659 AA has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · AC

GSS unscored target

Not used for pathway scoring

rs6088659 AC has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · AG

GSS unscored target

Not used for pathway scoring

rs6088659 AG has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · AT

GSS unscored target

Not used for pathway scoring

rs6088659 AT has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · CC

GSS unscored target

Not used for pathway scoring

rs6088659 CC has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · CG

GSS unscored target

Not used for pathway scoring

rs6088659 CG has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · CT

GSS unscored target

Not used for pathway scoring

rs6088659 CT has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · GG

GSS unscored target

Not used for pathway scoring

rs6088659 GG has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · GT

GSS unscored target

Not used for pathway scoring

rs6088659 GT has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

unknown · TT

GSS unscored target

Not used for pathway scoring

rs6088659 TT has no scored directional claim for GSS unscored target.

No reliable end-user genotype effect is assigned for GSS rs6088659. All listed genotypes are treated as unscored in this simplified file.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP lists rs6088659 as a single-nucleotide variant with A, C, G, and T alleles on the preferred placement. NCBI transcript annotation includes GSS, supporting the broad gene label used here.PMC3414259functional assay · loose proxyA COPD genetics study describes rs6088659 as an intron 1 GSS variant and says it may be in linkage disequilibrium with a splicing-related variant. The article also states that functional studies are needed, so this simplified record does not assign a directional effect.

Common symptoms people report

  • sulfur / transsulfuration can overlap with more persistent symptom patterns
  • marker-driven follow-up may matter more than generic advice
  • mixed responses can make the pathway easier to miss without structured review

Biomarkers to validate

Glutathione context

Primary follow-up marker for GSS inside sulfur / transsulfuration.

Related pathway markers

Useful when the pathway needs to be validated as a system rather than as one variant.

Where DNA analysis helps

DNA helps decide whether GSS should move sulfur / transsulfuration higher on the follow-up list before broad interventions are assumed.

Example interpretation

GSS can strengthen the case for sulfur / transsulfuration follow-up when the rest of the pathway points in a similar direction.

Suggested validation: Glutathione context.

What to do next

  • Use Glutathione context and pathway context before assuming the gene matters in practice.
  • Read GSS alongside the related genes in the same pathway instead of as a standalone result.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

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Related pages

GCLC

GCLC glutathione synthesis gene

SUOX

SUOX gene DNA analysis

Choline status

choline status and methyl donor support

Cysteine, sulfate, and transsulfuration

Cysteine, sulfate, and transsulfuration DNA follow-up

Sulfur and transsulfuration pathway

sulfur transsulfuration pathway

B12 transport and recycling pathway

B12 transport and recycling pathway

How accurate are DNA metabolism reports?

how accurate are DNA metabolism reports

23andMe vs Metastate metabolism report

23andMe vs Metastate metabolism report

Related symptom angle

Poor detoxification symptoms

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