What is the SLC22A1 gene?
OCT1 hepatic transporter influencing metformin disposition and glucose-control pharmacogenomic context.
How SLC22A1 affects metabolism
When SLC22A1-related function is shifted, the practical effect is interpreted through meal response, fasting glucose control, insulin signaling, or glucose transport. This does not mean the pathway is active or impaired right now; it means the gene can help prioritize what to check next.
What happens when SLC22A1 is altered
Altered SLC22A1 signal should be treated as a DNA-based tendency, not a diagnosis. 2 claims currently pass the report-use gate. The useful question is whether symptoms, labs, and lifestyle context line up with the pathway signal.
Curated SNP evidence for SLC22A1
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
SLC22A1 currently has 2 curated SNPs, 2 claim-level scores, and 2 claims eligible for pathway scoring.
Open the sample reportrs12208357R61C1 claims · 2 study rows
transport activity · T
OCT1 transport activity
rs12208357 T is associated with reduced SLC22A1/OCT1 transport activity.
SLC22A1 rs12208357 T is staged as a reduced OCT1 transport allele, mainly supported by metformin pharmacogenomic evidence.
Show study evidence
rs34130495G401S1 claims · 1 study rows
transport activity · A
OCT1 transport activity
rs34130495 A / OCT1 Gly401Ser is associated with reduced SLC22A1/OCT1 transport activity.
SLC22A1 rs34130495 A is staged as an OCT1 reduced-function allele, mainly relevant to metformin and organic-cation uptake.
Common symptoms people report
- sleepiness or fog after carbohydrate-heavy meals
- energy swings between meals
- family or lab concern around glucose markers
Biomarkers to validate
Fasting glucose and HbA1c
Checks baseline blood-sugar control.
Fasting insulin
Helps identify insulin-demand context that glucose alone can miss.
Triglycerides and HDL-C
Adds metabolic context around meal response and insulin resistance.
Where DNA analysis helps
DNA helps decide whether SLC22A1 deserves attention inside the broader Glucose pathway. It is most useful when combined with biomarkers instead of used as a standalone answer.
Example interpretation
SLC22A1 may add context to meal response, fasting glucose control, insulin signaling, or glucose transport, especially when its SNP evidence lines up with other genes in the same pathway.
Suggested validation: Fasting glucose and HbA1c.
What to do next
- Review the Glucose pathway result before interpreting SLC22A1 on its own.
- Use relevant biomarkers to confirm whether this DNA tendency is visible in current biology.
- Treat supplement or nutrition decisions as follow-up steps only after the pattern fits symptoms or labs.
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