What is the HADHA gene?
Mitochondrial trifunctional protein alpha subunit containing long-chain 3-hydroxyacyl-CoA dehydrogenase activity for long-chain fatty-acid beta-oxidation.
How HADHA affects metabolism
When HADHA-related function is shifted, the practical effect is interpreted through fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. This does not mean the pathway is active or impaired right now; it means the gene can help prioritize what to check next.
What happens when HADHA is altered
Altered HADHA signal should be treated as a DNA-based tendency, not a diagnosis. 1 claim currently passes the report-use gate. The useful question is whether symptoms, labs, and lifestyle context line up with the pathway signal.
Curated SNP evidence for HADHA
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
HADHA currently has 1 curated SNPs, 1 claim-level scores, and 1 claims eligible for pathway scoring.
Open the sample reportrs137852769HADHA c.1528G>C / Glu510Gln1 claims · 2 study rows
enzyme activity · GG
LCHAD activity tendency
rs137852769 GG, corresponding to HADHA c.1528G>C / p.Glu510Gln in transcript orientation, is associated with markedly lower long-chain 3-hydroxyacyl-CoA dehydrogenase activity tendency.
HADHA rs137852769 G is staged as the forward-genomic recessive LCHAD deficiency allele affecting mitochondrial long-chain fatty-acid oxidation.
Show study evidence
Common symptoms people report
- low energy under fasting, illness, or exercise
- slow recovery after exertion
- fatigue that feels out of proportion to workload
Biomarkers to validate
CBC, ferritin, and thyroid context
Rules out common non-DNA explanations for low energy.
Glucose and HbA1c
Checks whether fuel handling is adding pressure.
Organic acids or acylcarnitines when available
Adds more specific mitochondrial and fatty-acid oxidation context.
Where DNA analysis helps
DNA helps decide whether HADHA deserves attention inside the broader Mitochondrial energy pathway. It is most useful when combined with biomarkers instead of used as a standalone answer.
Example interpretation
HADHA may add context to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism, especially when its SNP evidence lines up with other genes in the same pathway.
Suggested validation: CBC, ferritin, and thyroid context.
What to do next
- Review the Mitochondrial energy pathway result before interpreting HADHA on its own.
- Use relevant biomarkers to confirm whether this DNA tendency is visible in current biology.
- Treat supplement or nutrition decisions as follow-up steps only after the pattern fits symptoms or labs.
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