What is the ETFDH gene?
FAD-dependent electron-transfer flavoprotein dehydrogenase connecting acyl-CoA dehydrogenases to the mitochondrial respiratory chain.
How ETFDH affects metabolism
When ETFDH-related function is shifted, the practical effect is interpreted through fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism. This does not mean the pathway is active or impaired right now; it means the gene can help prioritize what to check next.
What happens when ETFDH is altered
Altered ETFDH signal should be treated as a DNA-based tendency, not a diagnosis. 1 claim currently passes the report-use gate. The useful question is whether symptoms, labs, and lifestyle context line up with the pathway signal.
Curated SNP evidence for ETFDH
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
ETFDH currently has 1 curated SNPs, 1 claim-level scores, and 1 claims eligible for pathway scoring.
Open the sample reportrs121964954ETFDH c.250G>A / Ala84Thr1 claims · 3 study rows
enzyme activity · AA or compound-heterozygous ETFDH deficiency context
Electron-transfer flavoprotein dehydrogenase activity tendency
rs121964954 A / ETFDH c.250G>A / p.Ala84Thr is associated with lower electron-transfer flavoprotein dehydrogenase activity tendency and riboflavin-responsive multiple acyl-CoA dehydrogenase disruption in recessive or compound-heterozygous deficiency contexts.
ETFDH rs121964954 A is staged as a recessive MADD allele affecting FAD-dependent mitochondrial electron transfer from acyl-CoA dehydrogenases.
Show study evidence
Common symptoms people report
- low energy under fasting, illness, or exercise
- slow recovery after exertion
- fatigue that feels out of proportion to workload
Biomarkers to validate
CBC, ferritin, and thyroid context
Rules out common non-DNA explanations for low energy.
Glucose and HbA1c
Checks whether fuel handling is adding pressure.
Organic acids or acylcarnitines when available
Adds more specific mitochondrial and fatty-acid oxidation context.
Where DNA analysis helps
DNA helps decide whether ETFDH deserves attention inside the broader Mitochondrial energy pathway. It is most useful when combined with biomarkers instead of used as a standalone answer.
Example interpretation
ETFDH may add context to fatty-acid oxidation, mitochondrial transport, organic-acid handling, or high-demand energy metabolism, especially when its SNP evidence lines up with other genes in the same pathway.
Suggested validation: CBC, ferritin, and thyroid context.
What to do next
- Review the Mitochondrial energy pathway result before interpreting ETFDH on its own.
- Use relevant biomarkers to confirm whether this DNA tendency is visible in current biology.
- Treat supplement or nutrition decisions as follow-up steps only after the pattern fits symptoms or labs.
Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.
Get My DNA Report