What is the SLC2A2 gene?
GLUT2 facilitative glucose transporter involved in hepatic glucose handling and beta-cell or portal glucose sensing.
How SLC2A2 affects metabolism
When SLC2A2-related function is shifted, the practical effect is interpreted through meal response, fasting glucose control, insulin signaling, or glucose transport. This does not mean the pathway is active or impaired right now; it means the gene can help prioritize what to check next.
What happens when SLC2A2 is altered
Altered SLC2A2 signal should be treated as a DNA-based tendency, not a diagnosis. 3 claims currently pass the report-use gate. The useful question is whether symptoms, labs, and lifestyle context line up with the pathway signal.
Curated SNP evidence for SLC2A2
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
SLC2A2 currently has 3 curated SNPs, 3 claim-level scores, and 3 claims eligible for pathway scoring.
Open the sample reportrs121909742SLC2A2 p.Arg365Ter1 claims · 2 study rows
transport activity · AA or compound-heterozygous SLC2A2 deficiency context
GLUT2 glucose transport activity tendency
rs121909742 A on the genomic plus strand / SLC2A2 c.1093C>T / p.Arg365Ter is associated with lower GLUT2 glucose transport activity tendency in recessive or compound-heterozygous Fanconi-Bickel contexts.
SLC2A2 rs121909742 A is staged as a recessive truncating GLUT2 allele affecting glucose and galactose transport biology.
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rs121909743SLC2A2 p.Arg301Ter1 claims · 2 study rows
transport activity · AA or compound-heterozygous SLC2A2 deficiency context
GLUT2 glucose transport activity tendency
rs121909743 A on the genomic plus strand / SLC2A2 p.Arg301Ter is associated with lower GLUT2 glucose transport activity tendency in recessive or compound-heterozygous Fanconi-Bickel contexts.
SLC2A2 rs121909743 A is staged as a recessive truncating GLUT2 allele affecting glucose and galactose transport biology.
Show study evidence
rs5400SLC2A2 p.Thr110Ile1 claims · 2 study rows
biomarker tendency · A / p.Thr110Ile
fasting glucose and HbA1c tendency
rs5400 A at SLC2A2 is associated with lower fasting glucose and HbA1c tendency in large glycemic-trait association data.
SLC2A2 rs5400 A is staged as a glycemic biomarker-lowering GLUT2-locus signal.
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Common symptoms people report
- sleepiness or fog after carbohydrate-heavy meals
- energy swings between meals
- family or lab concern around glucose markers
Biomarkers to validate
Fasting glucose and HbA1c
Checks baseline blood-sugar control.
Fasting insulin
Helps identify insulin-demand context that glucose alone can miss.
Triglycerides and HDL-C
Adds metabolic context around meal response and insulin resistance.
Where DNA analysis helps
DNA helps decide whether SLC2A2 deserves attention inside the broader Glucose pathway. It is most useful when combined with biomarkers instead of used as a standalone answer.
Example interpretation
SLC2A2 may add context to meal response, fasting glucose control, insulin signaling, or glucose transport, especially when its SNP evidence lines up with other genes in the same pathway.
Suggested validation: Fasting glucose and HbA1c.
What to do next
- Review the Glucose pathway result before interpreting SLC2A2 on its own.
- Use relevant biomarkers to confirm whether this DNA tendency is visible in current biology.
- Treat supplement or nutrition decisions as follow-up steps only after the pattern fits symptoms or labs.
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