← Back to Knowledge Base

Primary topic: TMPRSS6 gene DNA analysis

TMPRSS6 Gene and Metabolism: What It Can Mean in a Pathway Report

TMPRSS6 becomes more useful when iron handling looks like a meaningful follow-up area instead of just background context.

What is the TMPRSS6 gene?

TMPRSS6 contributes to hepcidin regulation and functional iron availability. That makes it more useful as part of a pathway view than as an isolated SNP call.

How TMPRSS6 affects metabolism

If TMPRSS6-related support is less favorable, the pathway can look more pressured under load and the linked biomarkers become more useful to validate directly.

What happens when TMPRSS6 is altered

An altered TMPRSS6 pattern does not diagnose anything on its own, but it does change which follow-up markers deserve attention first.

Curated SNP evidence for TMPRSS6

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Iron handling

Evidence-backed report connection

TMPRSS6 currently has 3 curated SNPs, 21 claim-level scores, and 3 claims eligible for pathway scoring.

Open the sample report
rs2235321TMPRSS6 hepcidin supporting signal1 claims · 3 study rows

biomarker tendency · AG

serum hepcidin tendency

Moderate

rs2235321 AG carries one A allele in TMPRSS6 and is associated with lower serum hepcidin tendency.

TMPRSS6 rs2235321 AG is staged as a modest lower-hepcidin biomarker genotype relevant to iron restriction and iron response context.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportStrong support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP identity was checked to confirm rs2235321 labels and observed alleles at the TMPRSS6 locus. This row contributes no directional score.Jallow et al. 2021 Scientific Reportsbiomarker association · directIn 1,316 healthy rural Gambian participants, rs2235321 AA was associated with lower plasma hepcidin than GG after adjustment for inflammation, age, and sex; the authors reported about 19% lower hepcidin in AA and an approximate 9.5% single-allele effect, while other iron markers were not materially affected.Jallow et al. 2021 Current Developments in Nutritionbiomarker association · directA recall-by-genotype oral iron study in healthy Gambian adults reported higher baseline hepcidin in rs2235321 GG than AA participants and no clear difference in plasma iron response after oral iron. This supports a lower-hepcidin tendency for A while keeping the claim limited to hepcidin context.
rs4820268TMPRSS6 supporting signal10 claims · 30 study rows

biomarker tendency · GG

TMPRSS6 biomarker tendency

Moderate

rs4820268 GG is associated with reduced TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · AG

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 AG is associated with reduced TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · AA

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 AA has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · AC

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 AC has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · AT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 AT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · CC

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 CC has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · CG

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 CG has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · CT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 CT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · GT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 GT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.

biomarker tendency · TT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs4820268 TT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs4820268 is scored as a tendency toward lower iron-status biomarkers for the common G allele, strongest for GG and weaker for AG.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP places rs4820268 in TMPRSS6 and lists A, C, G, and T as observed letters on the preferred genomic placement. This supports using the current dbSNP genotype letters and treating non-A/G calls cautiously.PMC3043660gwas · close proxyA human iron-status meta-analysis and replication study reported that rs4820268 in TMPRSS6 was associated with iron-related markers. Compared with AA, GG was associated with lower serum iron, hemoglobin, MCV, and MCH and higher transferrin-related markers; hepcidin mRNA and urinary hepcidin results were borderline and need cautious interpretation.PubMed 38341535biomarker association · loose proxyA smaller pediatric pilot study reported that rs4820268 GG had the highest hepcidin gene-expression fold and the lowest serum ferroportin and iron-store measures compared with AA and AG. This supports a conservative lower iron-status biomarker tendency for GG, while keeping the heterozygote effect smaller.
rs855791V736A10 claims · 30 study rows

biomarker tendency · AA

TMPRSS6 biomarker tendency

Moderate

rs855791 AA is associated with reduced TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectLower biomarker tendency
Signal sizeSmall signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · AG

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 AG is associated with reduced TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectLower biomarker tendency
Signal sizeMinimal signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · AC

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 AC has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · AT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 AT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · CC

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 CC has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · CG

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 CG has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · CT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 CT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · GG

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 GG has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · GT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 GT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

biomarker tendency · TT

TMPRSS6 biomarker tendency

Not used for pathway scoring

rs855791 TT has no scored directional claim for TMPRSS6 biomarker tendency.

TMPRSS6 rs855791 is scored as a modest tendency toward lower iron-related blood biomarkers for common A-containing genotypes, strongest for AA and weaker for AG. Genotypes containing rarer C or T letters are left unscored because the public evidence does not support a simple end-user direction for them.

Likely effectNo clear biomarker tendency
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data identify rs855791 as a TMPRSS6 coding missense variant and list A, C, G, and T as observed genomic letters. This supports a TMPRSS6 biomarker-tendency record with neutral handling for rare letters that lack clear end-user evidence.PubMed 19820698gwas · close proxyA genome-wide association study reported rs855791 as the strongest TMPRSS6 signal for hemoglobin, with lower hemoglobin per copy of the A allele. This supports a conservative lower iron-related biomarker tendency for common A-containing genotypes.PubMed 19820699gwas · close proxyAn independent genome-wide study associated rs855791 in TMPRSS6 with serum iron, transferrin saturation, erythrocyte mean cell volume, and suggestive hemoglobin differences. This supports interpreting the score as an iron-related biomarker tendency rather than a diagnosis.

Common symptoms people report

  • iron handling can overlap with more persistent symptom patterns
  • marker-driven follow-up may matter more than generic advice
  • mixed responses can make the pathway easier to miss without structured review

Biomarkers to validate

Iron saturation

Primary follow-up marker for TMPRSS6 inside iron handling.

Related pathway markers

Useful when the pathway needs to be validated as a system rather than as one variant.

Where DNA analysis helps

DNA helps decide whether TMPRSS6 should move iron handling higher on the follow-up list before broad interventions are assumed.

Example interpretation

TMPRSS6 can strengthen the case for iron handling follow-up when the rest of the pathway points in a similar direction.

Suggested validation: Iron saturation.

What to do next

  • Use Iron saturation and pathway context before assuming the gene matters in practice.
  • Read TMPRSS6 alongside the related genes in the same pathway instead of as a standalone result.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

Get My DNA Report

Related pages

HFE

HFE gene DNA analysis

TFR2

TFR2 gene DNA analysis

Ferritin and iron storage

Ferritin and iron storage DNA follow-up

Ferritin and inflammatory context

Ferritin and inflammatory context DNA follow-up

Gluten and celiac immune risk pathway

gluten celiac immune risk pathway

Iron handling and storage pathway

iron handling storage pathway

How accurate are DNA metabolism reports?

how accurate are DNA metabolism reports

23andMe vs Metastate metabolism report

23andMe vs Metastate metabolism report

Related symptom angle

Low energy metabolism causes

Browse the knowledge base

See the full index of gene guides, biomarker guides, pathway guides, symptoms, buyer pages, and common questions.