What is the NCF2 gene?
NCF2 contributes to immune oxidative burst biology. In this report it is used as non-HLA immune context, not as a gluten intolerance marker.
How NCF2 affects metabolism
A NCF2 celiac signal may add modest immune background, but it cannot diagnose celiac disease or explain symptoms on its own.
What happens when NCF2 is altered
NCF2 should be interpreted after HLA-DQ context and serology, not before them.
Curated SNP evidence for NCF2
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
NCF2 currently has 1 curated SNPs, 1 claim-level scores, and 1 claims eligible for pathway scoring.
Open the sample reportrs17849502NCF2 celiac susceptibility signal1 claims · 3 study rows
disease trait · GT
Non-HLA NCF2 celiac susceptibility context
rs17849502 GT carries one GWAS Catalog celiac disease risk T allele at the NCF2 immune locus.
NCF2 rs17849502 GT is scored as small non-HLA celiac susceptibility context.
Show study evidence
Common symptoms people report
- digestive symptoms where celiac testing is relevant
- family context around autoimmune disease
- small-effect immune SNP findings
Biomarkers to validate
tTG-IgA with total IgA
Primary celiac screening context.
EMA or DGP context
Adds follow-up context when clinically appropriate.
Formal HLA-DQ typing
Clarifies genetic celiac compatibility better than non-HLA SNPs.
Where DNA analysis helps
DNA helps include NCF2 only as part of a broader immune-risk pattern.
Example interpretation
NCF2 may add useful context when its SNP evidence lines up with the broader pathway signal.
Suggested validation: celiac serology and HLA-DQ context.
What to do next
- Keep NCF2 as low-impact context.
- Do not infer gluten intolerance from this gene alone.
- Use serology and clinical evaluation for real celiac questions.
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