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Primary topic: BCAM gene choline and methyl-donor support

BCAM Gene and Metabolism: What It Can Mean in a Pathway Report

BCAM is tracked because it connects to choline intake need, phosphatidylcholine support, liver fat handling, or methyl-donor backup. The current evidence index links this gene to Choline support with 1 SNP and 6 curated claims.

What is the BCAM gene?

Basal-cell adhesion molecule locus included as a choline-support context marker in the current evidence set.

How BCAM affects metabolism

When BCAM-related function is shifted, the practical effect is interpreted through choline intake need, phosphatidylcholine support, liver fat handling, or methyl-donor backup. This does not mean the pathway is active or impaired right now; it means the gene can help prioritize what to check next.

What happens when BCAM is altered

Altered BCAM signal should be treated as a DNA-based tendency, not a diagnosis. 3 claims currently pass the report-use gate. The useful question is whether symptoms, labs, and lifestyle context line up with the pathway signal.

Curated SNP evidence for BCAM

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Choline support

Evidence-backed report connection

BCAM currently has 1 curated SNPs, 6 claim-level scores, and 2 claims eligible for pathway scoring.

Open the sample report
rs3810141SLC44A1 supporting signal6 claims · 12 study rows

expression · AA

BCAM gene expression

Not used for pathway scoring

rs3810141 AA is associated with reduced BCAM gene expression.

BCAM rs3810141 is scored as a reduced BCAM protein-expression tendency only for A-containing genotypes; common C/T genotypes are not scored as a clear effect in this simplified record.

Likely effectLower gene expression signal
Signal sizeLarge signal
Evidence supportModerate support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3810141 in BCAM, the basal cell adhesion molecule gene, and annotate the variant as stop gained in BCAM. The RefSNP record includes C, A, and T letters, so this file only scores A-containing calls as the loss-of-function side.ClinVar recordclinical curation · close proxyClinVar links rs3810141 to NM_005581.5(BCAM):c.711C>A, p.Cys237Ter, and the recessive Lutheran-null blood group phenotype. The submission description reports a healthy homozygous individual and heterozygous relatives, supporting a protein-loss interpretation without broad health-risk claims.

expression · AC

BCAM gene expression

Moderate

rs3810141 AC is associated with reduced BCAM gene expression.

BCAM rs3810141 is scored as a reduced BCAM protein-expression tendency only for A-containing genotypes; common C/T genotypes are not scored as a clear effect in this simplified record.

Likely effectLower gene expression signal
Signal sizeModerate signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3810141 in BCAM, the basal cell adhesion molecule gene, and annotate the variant as stop gained in BCAM. The RefSNP record includes C, A, and T letters, so this file only scores A-containing calls as the loss-of-function side.ClinVar recordclinical curation · close proxyClinVar links rs3810141 to NM_005581.5(BCAM):c.711C>A, p.Cys237Ter, and the recessive Lutheran-null blood group phenotype. The submission description reports a healthy homozygous individual and heterozygous relatives, supporting a protein-loss interpretation without broad health-risk claims.

expression · AT

BCAM gene expression

Moderate

rs3810141 AT is associated with reduced BCAM gene expression.

BCAM rs3810141 is scored as a reduced BCAM protein-expression tendency only for A-containing genotypes; common C/T genotypes are not scored as a clear effect in this simplified record.

Likely effectLower gene expression signal
Signal sizeModerate signal
Evidence supportModerate support
Report useIncluded in pathway scoring
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3810141 in BCAM, the basal cell adhesion molecule gene, and annotate the variant as stop gained in BCAM. The RefSNP record includes C, A, and T letters, so this file only scores A-containing calls as the loss-of-function side.ClinVar recordclinical curation · close proxyClinVar links rs3810141 to NM_005581.5(BCAM):c.711C>A, p.Cys237Ter, and the recessive Lutheran-null blood group phenotype. The submission description reports a healthy homozygous individual and heterozygous relatives, supporting a protein-loss interpretation without broad health-risk claims.

expression · CC

BCAM gene expression

Not used for pathway scoring

rs3810141 CC has no scored directional claim for BCAM gene expression.

BCAM rs3810141 is scored as a reduced BCAM protein-expression tendency only for A-containing genotypes; common C/T genotypes are not scored as a clear effect in this simplified record.

Likely effectNo clear expression signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3810141 in BCAM, the basal cell adhesion molecule gene, and annotate the variant as stop gained in BCAM. The RefSNP record includes C, A, and T letters, so this file only scores A-containing calls as the loss-of-function side.ClinVar recordclinical curation · close proxyClinVar links rs3810141 to NM_005581.5(BCAM):c.711C>A, p.Cys237Ter, and the recessive Lutheran-null blood group phenotype. The submission description reports a healthy homozygous individual and heterozygous relatives, supporting a protein-loss interpretation without broad health-risk claims.

expression · CT

BCAM gene expression

Not used for pathway scoring

rs3810141 CT has no scored directional claim for BCAM gene expression.

BCAM rs3810141 is scored as a reduced BCAM protein-expression tendency only for A-containing genotypes; common C/T genotypes are not scored as a clear effect in this simplified record.

Likely effectNo clear expression signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3810141 in BCAM, the basal cell adhesion molecule gene, and annotate the variant as stop gained in BCAM. The RefSNP record includes C, A, and T letters, so this file only scores A-containing calls as the loss-of-function side.ClinVar recordclinical curation · close proxyClinVar links rs3810141 to NM_005581.5(BCAM):c.711C>A, p.Cys237Ter, and the recessive Lutheran-null blood group phenotype. The submission description reports a healthy homozygous individual and heterozygous relatives, supporting a protein-loss interpretation without broad health-risk claims.

expression · TT

BCAM gene expression

Not used for pathway scoring

rs3810141 TT has no scored directional claim for BCAM gene expression.

BCAM rs3810141 is scored as a reduced BCAM protein-expression tendency only for A-containing genotypes; common C/T genotypes are not scored as a clear effect in this simplified record.

Likely effectNo clear expression signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data place rs3810141 in BCAM, the basal cell adhesion molecule gene, and annotate the variant as stop gained in BCAM. The RefSNP record includes C, A, and T letters, so this file only scores A-containing calls as the loss-of-function side.ClinVar recordclinical curation · close proxyClinVar links rs3810141 to NM_005581.5(BCAM):c.711C>A, p.Cys237Ter, and the recessive Lutheran-null blood group phenotype. The submission description reports a healthy homozygous individual and heterozygous relatives, supporting a protein-loss interpretation without broad health-risk claims.

Common symptoms people report

  • low choline intake may matter more than average
  • liver or triglyceride markers that deserve context
  • methylation support questions not explained by folate alone

Biomarkers to validate

ALT, AST, and GGT

Adds liver handling context.

Triglycerides

Helps check lipid and liver-fat context.

Homocysteine

Connects choline support to methylation demand.

Where DNA analysis helps

DNA helps decide whether BCAM deserves attention inside the broader Choline support pathway. It is most useful when combined with biomarkers instead of used as a standalone answer.

Example interpretation

BCAM may add context to choline intake need, phosphatidylcholine support, liver fat handling, or methyl-donor backup, especially when its SNP evidence lines up with other genes in the same pathway.

Suggested validation: ALT, AST, and GGT.

What to do next

  • Review the Choline support pathway result before interpreting BCAM on its own.
  • Use relevant biomarkers to confirm whether this DNA tendency is visible in current biology.
  • Treat supplement or nutrition decisions as follow-up steps only after the pattern fits symptoms or labs.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

Get My DNA Report

Related pages

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PEMT gene choline metabolism

BHMT

BHMT gene function

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choline status and methyl donor support

Liver enzymes

liver enzymes and choline support

Choline and phosphatidylcholine pathway

choline and phosphatidylcholine pathway

B12 transport and recycling pathway

B12 transport and recycling pathway

Can DNA predict metabolism?

can DNA predict metabolism

23andMe vs Metastate metabolism report

23andMe vs Metastate metabolism report

Related symptom angle

Why supplements do not work for me

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