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Primary topic: AHR gene DNA analysis

AHR Gene and Metabolism: What It Can Mean in a Pathway Report

AHR becomes more useful when caffeine / stimulant sensitivity looks like a meaningful follow-up area instead of just background context.

What is the AHR gene?

AHR contributes to induction signaling behind caffeine metabolism. That makes it more useful as part of a pathway view than as an isolated SNP call.

How AHR affects metabolism

If AHR-related support is less favorable, the pathway can look more pressured under load and the linked biomarkers become more useful to validate directly.

What happens when AHR is altered

An altered AHR pattern does not diagnose anything on its own, but it does change which follow-up markers deserve attention first.

Curated SNP evidence for AHR

These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.

Caffeine / stimulant sensitivity

Evidence-backed report connection

AHR currently has 2 curated SNPs, 6 claim-level scores, and 0 claims eligible for pathway scoring.

Open the sample report
rs4410790AHR supporting signal3 claims · 9 study rows

unknown · CC

AHR unscored target

Not used for pathway scoring

rs4410790 CC has no scored directional claim for AHR unscored target.

rs4410790 is treated as an AHR-region caffeine-intake association marker, not as a direct standalone measure of AHR expression or caffeine-metabolism activity.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data list C and T as observed letters for rs4410790. The RefSNP placement is near the AHR locus rather than a coding change in AHR.PMC3071630gwas · close proxyA genome-wide meta-analysis identified rs4410790, located about 54 kb upstream of AHR, as a strong marker for habitual caffeine consumption. The paper describes AHR as biologically plausible because AHR regulates CYP1A2, a major caffeine-metabolizing enzyme.Evidence 3gwas · loose proxyThe PubMed-indexed abstract reports that the 7p21 region near AHR and the 15q24 CYP1A1-CYP1A2 region were associated with habitual caffeine intake in people of European descent.

unknown · CT

AHR unscored target

Not used for pathway scoring

rs4410790 CT has no scored directional claim for AHR unscored target.

rs4410790 is treated as an AHR-region caffeine-intake association marker, not as a direct standalone measure of AHR expression or caffeine-metabolism activity.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data list C and T as observed letters for rs4410790. The RefSNP placement is near the AHR locus rather than a coding change in AHR.PMC3071630gwas · close proxyA genome-wide meta-analysis identified rs4410790, located about 54 kb upstream of AHR, as a strong marker for habitual caffeine consumption. The paper describes AHR as biologically plausible because AHR regulates CYP1A2, a major caffeine-metabolizing enzyme.Evidence 3gwas · loose proxyThe PubMed-indexed abstract reports that the 7p21 region near AHR and the 15q24 CYP1A1-CYP1A2 region were associated with habitual caffeine intake in people of European descent.

unknown · TT

AHR unscored target

Not used for pathway scoring

rs4410790 TT has no scored directional claim for AHR unscored target.

rs4410790 is treated as an AHR-region caffeine-intake association marker, not as a direct standalone measure of AHR expression or caffeine-metabolism activity.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data list C and T as observed letters for rs4410790. The RefSNP placement is near the AHR locus rather than a coding change in AHR.PMC3071630gwas · close proxyA genome-wide meta-analysis identified rs4410790, located about 54 kb upstream of AHR, as a strong marker for habitual caffeine consumption. The paper describes AHR as biologically plausible because AHR regulates CYP1A2, a major caffeine-metabolizing enzyme.Evidence 3gwas · loose proxyThe PubMed-indexed abstract reports that the 7p21 region near AHR and the 15q24 CYP1A1-CYP1A2 region were associated with habitual caffeine intake in people of European descent.
rs6968865AHR supporting signal3 claims · 6 study rows

unknown · AA

AHR unscored target

Not used for pathway scoring

rs6968865 AA has no scored directional claim for AHR unscored target.

rs6968865 is treated as an AHR-region caffeine-intake association marker, not as a direct measure of AHR expression or CYP1A2 enzyme activity.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data list A and T as observed letters for rs6968865 on chromosome 7. This supports the genotype labels used here, but the RefSNP record alone does not establish a direct activity or expression effect.PMC3080612gwas · loose proxyA genome-wide study reported that rs6968865-T near AHR was associated with higher habitual coffee consumption. The authors described higher caffeine clearance through CYP1A1 or CYP1A2 activity as a possible explanation, while noting that this mechanism was not proven experimentally in that study.

unknown · AT

AHR unscored target

Not used for pathway scoring

rs6968865 AT has no scored directional claim for AHR unscored target.

rs6968865 is treated as an AHR-region caffeine-intake association marker, not as a direct measure of AHR expression or CYP1A2 enzyme activity.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data list A and T as observed letters for rs6968865 on chromosome 7. This supports the genotype labels used here, but the RefSNP record alone does not establish a direct activity or expression effect.PMC3080612gwas · loose proxyA genome-wide study reported that rs6968865-T near AHR was associated with higher habitual coffee consumption. The authors described higher caffeine clearance through CYP1A1 or CYP1A2 activity as a possible explanation, while noting that this mechanism was not proven experimentally in that study.

unknown · TT

AHR unscored target

Not used for pathway scoring

rs6968865 TT has no scored directional claim for AHR unscored target.

rs6968865 is treated as an AHR-region caffeine-intake association marker, not as a direct measure of AHR expression or CYP1A2 enzyme activity.

Likely effectNo clear DNA signal
Signal sizeMinimal signal
Evidence supportVery limited support
Report useEvidence only, not scored
Show study evidence
NCBI RefSNP recordidentity only · unknownNCBI RefSNP data list A and T as observed letters for rs6968865 on chromosome 7. This supports the genotype labels used here, but the RefSNP record alone does not establish a direct activity or expression effect.PMC3080612gwas · loose proxyA genome-wide study reported that rs6968865-T near AHR was associated with higher habitual coffee consumption. The authors described higher caffeine clearance through CYP1A1 or CYP1A2 activity as a possible explanation, while noting that this mechanism was not proven experimentally in that study.

Common symptoms people report

  • caffeine / stimulant sensitivity can overlap with more persistent symptom patterns
  • marker-driven follow-up may matter more than generic advice
  • mixed responses can make the pathway easier to miss without structured review

Biomarkers to validate

Sleep disruption pattern

Primary follow-up marker for AHR inside caffeine / stimulant sensitivity.

Related pathway markers

Useful when the pathway needs to be validated as a system rather than as one variant.

Where DNA analysis helps

DNA helps decide whether AHR should move caffeine / stimulant sensitivity higher on the follow-up list before broad interventions are assumed.

Example interpretation

AHR can strengthen the case for caffeine / stimulant sensitivity follow-up when the rest of the pathway points in a similar direction.

Suggested validation: Sleep disruption pattern.

What to do next

  • Use Sleep disruption pattern and pathway context before assuming the gene matters in practice.
  • Read AHR alongside the related genes in the same pathway instead of as a standalone result.

Upload your DNA file and receive a structured metabolic pathway analysis with prioritized insights and suggested validation markers.

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Related pages

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Caffeine clearance and response DNA follow-up

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Sleep disruption and stimulant load DNA follow-up

Caffeine and stimulant sensitivity pathway

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How accurate are DNA metabolism reports?

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Best DNA test for metabolism

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Related symptom angle

Why caffeine hits me hard genetics

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