What is the IL10 gene?
IL10 encodes an anti-inflammatory cytokine involved in immune tolerance and inflammatory balance.
How IL10 affects metabolism
An IL10 promoter signal can add weak persistence/tolerance context, but it does not diagnose cow-milk allergy and should not be mixed with lactose digestion.
What happens when IL10 is altered
An IL10 signal matters only when allergy history, IgE testing, clinician review, or food-challenge context supports the same pattern.
Curated SNP evidence for IL10
These SNPs come from the approved study-level evidence model. Each claim is scored from curated study rows, then gated before it can influence pathway scoring.
Evidence-backed report connection
IL10 currently has 1 curated SNPs, 1 claim-level scores, and 0 claims eligible for pathway scoring.
Open the sample reportrs1800896IL10 -1082G/A persistent cow-milk allergy candidate signal1 claims · 2 study rows
disease trait · GG
Persistent IgE-mediated cow milk allergy context
rs1800896 GG at the IL10 -1082G/A promoter polymorphism was associated with persistent IgE-mediated cow's milk allergy in a Brazilian pediatric cohort.
IL10 rs1800896 GG is retained as weak persistent cow-milk allergy immune-tolerance context only.
Show study evidence
Common symptoms people report
- persistent immediate-type dairy allergy symptoms
- history of cow-milk allergy that needs clinical follow-up
- dairy reactions that look immune-mediated rather than dose-related
Biomarkers to validate
cow-milk specific IgE
Supports or weakens an immediate-type cow-milk allergy question.
skin-prick testing
Adds allergy-sensitization context when symptoms fit.
allergist review
Helps decide whether formal food-challenge context is appropriate.
Where DNA analysis helps
DNA can help document weak immune-tolerance context, but allergy testing and clinical history are the decision layer.
Example interpretation
IL10 may add weak tolerance-context evidence when cow-milk allergy history is already clinically relevant.
Suggested validation: cow-milk specific IgE, symptom timing, and allergist review.
What to do next
- Do not use IL10 evidence to diagnose cow-milk allergy.
- Review whether symptoms are immediate allergy-type reactions or digestion symptoms.
- Use clinician-guided allergy testing before changing diet for allergy reasons.
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