What stands out
This is a meaningful pathway in the sample.
Working interpretation
The working read here is lower b12 transport support.
Key markers
methylmalonic acid, holotranscobalamin, B12
Priority context
High. This is one of the clearest and most testable findings in the report.
Why it rose
Why this pathway surfaced
This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.
methylmalonic acid
helps show whether active B12-dependent reactions look under-supported
holotranscobalamin
shows how much active circulating B12 is available for tissue delivery
B12
B12 gives practical context for whether b12 transport is showing up in real physiology.
Main genes
Which genes are carrying the signal
TCN2
TCN2 adds weight to the same pathway interpretation, but does not drive it alone.
TCN2 adds b12 transport context and should be interpreted with the surrounding pathway pattern, not on its own.
MTRR
MTRR adds weight to the same pathway interpretation, but does not drive it alone.
MTRR adds b12 transport context and should be interpreted with the surrounding pathway pattern, not on its own.
MTR
MTR adds weight to the same pathway interpretation, but does not drive it alone.
MTR adds b12 transport context and should be interpreted with the surrounding pathway pattern, not on its own.