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Uric acid / purine handling in the sample report

This page explains why this pathway rose in the sample report, what it likely means, and what to validate next.

Worth checking now

What stands out

This is a meaningful pathway in the sample.

What it likely means

Working interpretation

The working read here is lower uric acid / purine handling support.

What to check next

Key markers

Uric acid, eGFR / creatinine, purine-load context

How much to care

Priority context

High. This is one of the clearest and most testable findings in the report.

Why it rose

Why this pathway surfaced

This pathway tends to surface when several studied variants in its core genes point in a similar direction strongly enough to justify biomarker follow-up.

6 genes reviewed · 16 variant rows

Uric acid

Uric acid gives practical context for whether uric acid / purine handling is showing up in real physiology.

eGFR / creatinine

EGFR / creatinine gives practical context for whether uric acid / purine handling is showing up in real physiology.

purine-load context

Purine-load context gives practical context for whether uric acid / purine handling is showing up in real physiology.

Open report sectionOpen evidence appendixOpen evergreen topic guide

Main genes

Which genes are carrying the signal

ABCG2

Supporting contributor · Medium confidence

ABCG2 adds weight to the same pathway interpretation, but does not drive it alone.

ABCG2 adds uric acid / purine handling context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

SLC2A9

Supporting contributor · Medium confidence

SLC2A9 adds weight to the same pathway interpretation, but does not drive it alone.

SLC2A9 adds uric acid / purine handling context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

SLC22A12

Supporting contributor · Medium confidence

SLC22A12 adds weight to the same pathway interpretation, but does not drive it alone.

SLC22A12 adds uric acid / purine handling context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

XDH

Supporting contributor · Medium confidence

XDH adds weight to the same pathway interpretation, but does not drive it alone.

XDH adds uric acid / purine handling context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

TMPRSS6

Supporting contributor · Medium confidence

TMPRSS6 adds weight to the same pathway interpretation, but does not drive it alone.

TMPRSS6 adds uric acid / purine handling context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix

HFE

Supporting contributor · Medium confidence

HFE adds weight to the same pathway interpretation, but does not drive it alone.

HFE adds uric acid / purine handling context and should be interpreted with the surrounding pathway pattern, not on its own.

Open gene pageOpen appendix